| HRA003311
(Controlled Access)
|
We investigated the T cell receptor (TCR) repertoires in peripheral blood from 73 patients with OSA, 23 patients without OSA, and 157 healthy individuals. Strikingly, we found an unexpected increase in diversity and clonotypes in the TCR repertoire of OSA. Furthermore, relying on identifying a series of disease-associated clones, we successfully developed a novel indicator termed OSA-TCI to summarize the unique repertoire alteration, which provided 90% of sensitivity and 87% of specificity in distinguishing severe OSA. Furthermore, in rationalization, OSA-TCI was found correlated to AHI, BMI, hemoglobin, N1,N2 percentage of sleep, snoring, smoking and lowest oxygen saturation, but only independently related to AHI (R=0.603) and smoking (R=0.22). Finally, we observed a significant decrease in OSA-TCI in the eight severe patients after home noninvasive ventilation for three months during follow-up, consistently in line with TCR repertoire improvement. |
