| HRA006887
(Controlled Access)
|
This study aimed to identify differential gut microbiota between KRAS mutant and KRAS wild-type CRC patients by fecal 16S rRNA gene sequencing. We intended to analyze their correlations with immune infiltrating cells, immune-related genes and enriched biological functions, all of which will be derived from the analysis of mRNA sequencing data, aiming to demystify their roles in KRAS mutation and the progression of CRC. Moreover, we will employ these KRAS mutation-associated gut microbiota to construct a predictive machine learning model, offering fresh insights into for microbiological discovery and clinical prediction of KRAS mutation status for CRC patients. |