| 描述信息 |
All mice used in this paper are in a predominant C57Bl/6L background. Mice were divided into four groups, 15 mice in each group.The mice were housed in a temperature controlled, specific pathogen free environment, with a 12 h light/dark cycle. Male and female C57BL/6L mice at 8 weeks old were intraperitoneally injected with 10 mg/kg AOM (Merck, Darmstadt, Germany), followed by 3 cycles of DSS (MP Biomedicals, Solon, OH) administration to mimic colitis-associated CRC. For each cycle, mice were allowed free access to drinking water supplemented with 2.0% DSS for 7 days, followed by 14 days of regular water. Feces were taken from all mice at 18 weeks. |
