Endothelial cell

Cell Taxonomy ID: CT:00000153
Cell Ontology ID: CL:0000115
Synonyms: Endotheliocyte
Author: Dee Lauzon, Sue Lancelle, Marian Rice
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  • Endothelial cell is associated with 1492 cell markers in 56 conditions and 80 tissues across 7 species, supported by 280 publications.
  • Based on reported cell markers, the similarity score between Endothelial cell and Smooth muscle cell is 0.16.
  • Endothelial cell is distributed in 13 tissues in Tabula Sapiens (human) and 10 tissues in Tabula Muris (mouse).
  • For Endothelial cell, there are conserved cell markers whose orthologs are also reported as cell markers for this cell type.
  • The relevant cell markers of Endothelial cell are ranked in terms of supported literature, expression enrichment and conservation.
  • Show value
    No. of publications
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    log2FC
    The median log2 fold-change of expression (FDR < 0.05) in a cell cluster to that in all other cells among the available scRNA-seq samples

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    Highly expressed ratio
    Number of samples in which genes are more highly expressed in this cell type compared to other cell types (log2FC > 0.25, FDR < 0.05) divided by number of total samples for the cell type

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    Specificity score
    The median cell specificity score (calculated by Jensen-Shannon divergence score, ranging from 0 to 1) among available scRNA-seq samples

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    Conservation score
    Number of ortholog genes which are also reported as cell markers for this cell type in other species

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    		Total
No. of publications0306090120PECAM1VWFCD34VECADKDRCLDN5CD105FLT1MCAMRAMP2GNG11PTPRCFLT4LYVE1ERGTEKPLVAPTM4SF1EMCNELEECSCRTHBDTIE1VCAM1LDB2CLEC14AA2MELK3FABP4ADGRF5********************************************Endothelial cell: top publication-supported markers of Homo sapiens
ADGRF5FABP4ELK3A2MCLEC14ALDB2VCAM1TIE1THBDECSCRELEEMCNTM4SF1PLVAPTEKERGLYVE1FLT4PTPRCGNG11RAMP2MCAMFLT1CD105CLDN5KDRVECADCD34VWFPECAM1Adipose tissueAnterior hippocampusAorta-gonad-mesonephroBloodBlood plasmaBlood vesselBone marrowBone tissueBrainBreastCarotid artery segmentCerebral cortexChorionic villusColonCorneaCorpus luteumDental pulpDermisEmbryoEntorhinal cortexEsophagusEyeFemoral arteryGonadHead and neckHeartIntervertebral diskKidneyKidney (organoid)LiverLungLymph nodeLymphatic vesselMedian basilic veinMuscle organOmentumOral cavityOvaryPancreasPeritoneumPosterior hippocampusPrefrontal cortexRectus femorisRenal glomerulusSkeletal muscle organSkin of bodyStomachSubcutaneous adipose tissueTemporal lobeTestisThyroid glandUrinary bladderUveaWhite adipose tissue1513129855554444333333333322222222222222222222222222222222111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111015Number of publications in support of cell markers for Endothelial cell in Homo sapiens
Species Tissue Tissue ID Condition Disease ID Cell marker Source PMID
Cell marker expression enrichment
This panel shows the top cell markers highly and specifically expressed in this cell type.
Show publication-supported cell markers
Show publication-supported cell markers or rank cell markers by the y-axis value
Rank by highly expressed ratio
Cell marker No. of total samples (E) No. of highly expressed samples (HE, FDR<0.05) Highly expressed ratio (HE/E)
Species Sample Condition Cell marker log2FC Pct.cell type
The expression percentage of this gene in this cell type
Pct.others
The expression percentage of this gene in other cell types
P value FDR
Species Sample Condition Cell marker Cell specificity score
Jensen-Shannon (JS) divergence score (0-1) is calculated to quantify the cell type specificity of one cell marker (Cabili MN et al., 2011 ).
Cell surface marker
This panel shows the cell surface markers of this cell type predicted to have a membrane-bound protein product.
Cell marker No. of publications FDR
The FDR is calculated by fisher’s exact test to see if this cell marker is specifically associated with this cell type by publication.
Species Evidence Antibody Protein class
Cellular comparison across species
This panel compares marker composition of cell types across species. The cell markers and their orthologous genes which are also reported as cell markers for the same cell type are showed.
  • For Endothelial cell, the similarity of reported cell marker composition between different species is shown below.
Species in comparison Tissue Cell-type similarity across species
The cell-type similarity across species is evaluated by the number of orthologous cell markers divided by the union of cell markers in the two species
No. of orthologous cell markers
  • The conserved cell markers and their orthologous genes which are also reported as cell markers for the same cell type are showed below.
Cell marker Species (ortholog) Ortholog Gene ID (ortholog) No. of publications (ortholog cell markers)
Cellular similarity based on cell marker
This panel shows the similarity between this cell type and other cell types in marker composition. The more similar the cell types based on markers, the shorter the distance on the map.
Endothelial cell (non-professional APC)Stromal cellEndothelial cell (APC)Smooth muscle cellFibroblastGonadal endothelial cellMesenchymal stem cellEndothelial cell (endothelial to mesenchymal transMacrophageEpithelial cellChondrocyteBasal cellMesothelial cellStratified epithelial cellAstrocyteNeuronMonocyteT cellMicroglial cellProfessional antigen presenting cellDendritic cellEndothelial cell of hepatic sinusoidStem cellErythroid progenitor cellMast cellGoblet cellB cellMitotic fetal germ cellMyeloid cellNeutrophilEndothelial cell: similarity score of Homo sapiens
SpeciesTissueCell type in comparison Marker similarity score
The similarity score (0-1) is calculated between two cell types by the number of common markers normalized by union of marker set sizes. One represents the same marker sets of two cell types and zero means the two cell types share no common markers.
AllChorionic villusHematopoietic stem cell1
AllSubcutaneous adipose tissuePericyte0.67
AllSkeletal muscle organAdventitial cell0.6
AllAdipose tissuePericyte0.55
AllVisual cortexSmooth muscle cell0.5
Showing 1 to 5 of 2,110 entries
Cellular composition of tissues
This panel shows cell-type composition across human and mouse tissues in representative large-scale scRNA-seq studies (Tabula Sapiens Consortium and Tabula Muris Consortium).
Percentage (%)051015202530EyeFatKidneyLiverLymph nodePancreasProstateSalivary glandSkin of bodySpleenTracheaUterusVasculatureTissue distribution of Endothelial cell in Homo sapiens (Tabula Sapiens)
Cell cluster evaluation in scRNA-seq studies
This panel shows the evaluation of cell clusters of this cell type in available scRNA-seq samples. You can select samples of higher ROGUE index and Silhouette coefficient indicating less expression heterogeneity and larger difference between intra-cluster distance and inter-cluster, respectively.
Set the filters of cell number, ROGUE, silhouette coefficient, and their averaged estimates by adjusting the hover cursors of the legends.
Species Accession number Sample PMID Cell number ROGUE index
ROGUE is calculated to accurately quantify the purity of identified cell clusters. A ROGUE value greater than 0.9 indicates a cell cluster with high purity.
Silhouette coefficient
The Silhouette coefficient ranges from -1 to 1, and 1 means clusters are well apart from each other, 0 means clusters are indifferent, and -1 means clusters are defined in the wrong way.
Average ROGUE index
Mean ROGUE index of all cell clusters in the sample.
Average silhouette coefficient
Mean silhouette coefficient of all cell clusters in the sample.