Cardiovascular Disease Atlas
Data release 1.0
| Disease | Cardiomyopathy |
|---|---|
| CVD Atlas ID | CVDD000002 |
| MeSH ID | D009202 |
| Ontology ID | NCIT:C34830 |
| Description [MeSH] | A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). |
| Dataset | Reported disease | Tissue/cell type | Omics | Data accession |
|---|---|---|---|---|
| CVDS000534 | Cardiomyopathy | Induced pluripotent stem cell-derived cardiomyocyte | Transcriptomics | GSE121559 |
| Variant | Gene | Beta | Standard error | P value | Odds ratio | Study | Ancestry | Link |
|---|
| Gene | Tissue | Best coloc SNP | GWAS risk SNP | SNP.PP.H4 | PP.H4.abf | Ancestry | Dataset |
|---|
| Variant | Gene | Description | PMID |
|---|---|---|---|
| No data available in table | |||
| Variant | Pre miRNA | Region | Mature miRNA |
ΔG
|
Predict
| PMID |
|---|---|---|---|---|---|---|
| No data available in table | ||||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| Acute Coronary Syndrome | MIR605 | genetics_GWAS | We found that the miR-605 rs2043556 AG genotype significantly decreased the risk of acute myocardial infarction (odds ratio, OR = 0.13, 95%CI 0.02-0.96, P = .045) and that the rs2043556 GG genotype significantly decreased the risk of unstable angina (OR = 0.19, 95%CI 0.05-0.65, P = .008) in ACS patients receiving clopidogrel therapy for more than one year. The results demonstrate that miR-605 targets the mRNA of the CYP2B6 and P2RY12 genes, and that rs2043556 A/G polymorphisms in miR-605 modulate the mRNA and protein expression of CYP2B6 and P2RY12 differently, which may impact the effect of clopidogrel in ACS patients. | 31766967 |
| Tissue/cell type | Gene | Reported disease | Alteration | log2FC | P value | Adjusted P value | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| Plasma | hsa-mir-208b | Acute coronary syndrome | Up | 148 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-29a | Acute coronary syndrome | Up | 2.20 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-378a | Acute coronary syndrome | Up | 2.40 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-30a | Acute coronary syndrome | Up | 2.30 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-499a | Acute coronary syndrome | Up | 34.2 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-193a | Acute coronary syndrome | Up | 3.30 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-34a | Acute coronary syndrome | Up | 3.90 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-10b | Acute coronary syndrome | Up | 2.50 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-195 | Acute coronary syndrome | Up | 2.80 | NaN | - | RNA-seq | 31899480 |
| Plasma | hsa-mir-483 | Acute coronary syndrome | Up | 4.40 | NaN | - | RNA-seq | 31899480 |
| Tissue/cell type | Gene | Reported disease | Mapped disease | log2FC | P value | Adjusted P value | Method | Dataset |
|---|---|---|---|---|---|---|---|---|
| Blood | XIST | Acute coronary syndrome | Acute coronary syndrome | 22.2 | 4.29e-5 | 2.30e-3 | RNA-seq | CVDS000047 |
| Blood | RPPH1 | Acute coronary syndrome | Acute coronary syndrome | 12.2 | 1.99e-5 | 1.27e-3 | RNA-seq | CVDS000047 |
| Blood | SNORD3D | Acute coronary syndrome | Acute coronary syndrome | 11.7 | 4.94e-4 | 1.55e-2 | RNA-seq | CVDS000047 |
| Blood | ENSG00000284931 | Acute coronary syndrome | Acute coronary syndrome | 11.6 | 4.68e-7 | 6.09e-5 | RNA-seq | CVDS000047 |
| Blood | RNF182 | Acute coronary syndrome | Acute coronary syndrome | 11.4 | 7.04e-5 | 3.46e-3 | RNA-seq | CVDS000047 |
| Blood | HBG2 | Acute coronary syndrome | Acute coronary syndrome | 11.4 | 1.11e-6 | 1.22e-4 | RNA-seq | CVDS000047 |
| Blood | HBA1 | Acute coronary syndrome | Acute coronary syndrome | 11.3 | 3.74e-32 | 2.10e-28 | RNA-seq | CVDS000047 |
| Blood | HBA2 | Acute coronary syndrome | Acute coronary syndrome | 10.5 | 1.44e-22 | 2.30e-19 | RNA-seq | CVDS000047 |
| Blood | HBM | Acute coronary syndrome | Acute coronary syndrome | 10.5 | 1.11e-5 | 8.14e-4 | RNA-seq | CVDS000047 |
| Blood | SNORD45B | Acute coronary syndrome | Acute coronary syndrome | 10.4 | 1.68e-5 | 1.15e-3 | RNA-seq | CVDS000047 |
| Gene | Gene type | Species | Reported disease | Score | PMID | Gene link |
|---|
| Reported disease | Tissue | Gene | Effect size | P value | Method | Publication | PMID | Gene link |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| Acute Coronary Syndrome | hsa-mir-208b | circulation_biomarker_diagnosis_ns | In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS. | 36723013 |
| Acute Coronary Syndrome | hsa-mir-143 | circulation_biomarker_diagnosis_ns | In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS. | 36723013 |
| Acute Coronary Syndrome | MIR377 | circulation_biomarker_diagnosis_ns | The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. | 36549775 |
| Acute Coronary Syndrome | hsa-mir-145 | circulation_biomarker_diagnosis_ns | In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis. | 36241060 |
| Acute Coronary Syndrome | hsa-mir-143 | circulation_biomarker_diagnosis_ns | In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis. | 36241060 |
| Acute Coronary Syndrome | MIR497 | circulation_biomarker_diagnosis_up | Our study suggests that serum miR | 35302437 |
| Acute Coronary Syndrome | MIR646 | genetics_knock down_promote | The knockdown of miR-3646 could alleviate ACS by reversing inflammatory response. | 34519257 |
| Acute Coronary Syndrome | hsa-mir-222 | circulation_biomarker_diagnosis_up | Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis >/=50% and the occurrence of ACS. | 34330158 |
| Acute Coronary Syndrome | hsa-mir-221 | circulation_biomarker_diagnosis_up | Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis >/=50% and the occurrence of ACS. | 34330158 |
| Acute Coronary Syndrome | hsa-mir-221 | circulation_biomarker_diagnosis_up | RESULTS: The study data showed significant down regulation in the expression of the serum levels of FENDRR lncRNA and miRNA | 34208452 |
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Name | Gene | Relation to gene | Tissue | Reported disease | Delta beta | P value | Adjusted P value | Dataset | GEO accession |
|---|
| Name | Gene | Relation to gene | Reported disease | Delta beta | P value | Adjusted P value | Tissue | PMID |
|---|
| Reported disease | Gene | Category | Description | Publication |
|---|
| Reported disease | Gene | Species | Description | Publication |
|---|
| Gene | Protein | Average log2FC | P value | Dataset |
|---|
| Metabolite | VIP | Dataset |
|---|
| Chemical name | Chemical ID | Direct evidence | Reported disease | Inference gene | Inference score | #PMIDs | Gene link |
|---|