Cardiovascular Disease Atlas
Data release 1.0
| Disease | Ischemic stroke |
|---|---|
| CVD Atlas ID | CVDD000006 |
| MeSH ID | D000083242 |
| Ontology ID | NCIT:C95802 |
| Description [MeSH] | Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin. |
| Dataset | Reported disease | Tissue/cell type | Omics | Data accession |
|---|---|---|---|---|
| CVDS000164 | Ischemic stroke (small-vessel) | - | Genomics | GCST005841 |
| CVDS000171 | Ischemic stroke (small-vessel) | - | Genomics | GCST006909 |
| CVDS000163 | Ischemic stroke (large artery atherosclerosis) | - | Genomics | GCST005840 |
| CVDS000169 | Ischemic stroke (large artery atherosclerosis) | - | Genomics | GCST006907 |
| CVDS000165 | Ischemic stroke (cardioembolic) | - | Genomics | GCST005842 |
| Variant | Gene | Beta | Standard error | P value | Odds ratio | Study | Ancestry | Link |
|---|
| Gene | Tissue | Best coloc SNP | GWAS risk SNP | SNP.PP.H4 | PP.H4.abf | Ancestry | Dataset |
|---|
| Variant | Gene | Description | PMID |
|---|---|---|---|
| No data available in table | |||
| Variant | Pre miRNA | Region | Mature miRNA |
ΔG
|
Predict
| PMID |
|---|---|---|---|---|---|---|
| No data available in table | ||||||
| SNP | Reported disease | Gene | Description | PMID |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Tissue/cell type | Gene | Reported disease | Alteration | log2FC | P value | Adjusted P value | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| Plasma | circSCMH1 | Acute ischemic stroke | Down | 0.00 | <0.05 | - | qPCR | 32441115 |
| Plasma | hsa-mir-125a | Ischemic stroke | Up | 0.848 | - | - | qPCR | 28724745 |
| Plasma | hsa-mir-125b-1 | Ischemic stroke | Up | 1.32 | - | - | qPCR | 28724745 |
| Plasma | hsa-mir-143 | Ischemic stroke | Up | 2.26 | - | - | qPCR | 28724745 |
| Tissue/cell type | Gene | Reported disease | Mapped disease | log2FC | P value | Adjusted P value | Method | Dataset |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Gene | Gene type | Species | Reported disease | Score | PMID | Gene link |
|---|---|---|---|---|---|---|
| HIF1A-AS1 | lncRNA | Homo sapiens | Aneurysm | 0.695 | 25550800 | RNADisease |
| hsa-mir-132 | miRNA | Homo sapiens | Aneurysm | 0.329 | 26675167 | RNADisease |
| hsa-mir-141 | miRNA | Homo sapiens | Aneurysm | 0.329 | 30280445 | RNADisease |
| hsa-mir-145 | miRNA | Homo sapiens | Aneurysm | 0.329 | 29558369 | RNADisease |
| hsa-mir-200a | miRNA | Homo sapiens | Aneurysm | 0.329 | 30280445 | RNADisease |
| hsa-mir-200b | miRNA | Homo sapiens | Aneurysm | 0.329 | 30280445 | RNADisease |
| hsa-mir-200c | miRNA | Homo sapiens | Aneurysm | 0.329 | 30280445 | RNADisease |
| hsa-mir-24-1 | miRNA | Homo sapiens | Aneurysm | 0.636 | 29845232 | RNADisease |
| hsa-mir-26b | miRNA | Homo sapiens | Aneurysm | 0.329 | 33407182 | RNADisease |
| hsa-mir-3177 | miRNA | Homo sapiens | Aneurysm | 0.329 | 30354977 | RNADisease |
| Reported disease | Tissue | Gene | Effect size | P value | Method | Publication | PMID | Gene link |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Name | Gene | Relation to gene | Tissue | Reported disease | Delta beta | P value | Adjusted P value | Dataset | GEO accession |
|---|---|---|---|---|---|---|---|---|---|
| No data available in table | |||||||||
| Name | Gene | Relation to gene | Reported disease | Delta beta | P value | Adjusted P value | Tissue | PMID |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Gene | Protein | Average log2FC | P value | Dataset |
|---|---|---|---|---|
| No data available in table | ||||
| Metabolite | VIP | Dataset |
|---|---|---|
| No data available in table | ||
| Chemical name | Chemical ID | Direct evidence | Reported disease | Inference gene | Inference score | #PMIDs | Gene link |
|---|
Chemical name | Chemical ID | Direct evidence | Reported disease | Inference gene | Inference score | #PMIDs | Gene link |
|---|---|---|---|---|---|---|---|
| Amphetamine | D000661 | marker/mechanism | Aneurysm | - | 17989327|9786273 | - | |
| Cyclophosphamide | D003520 | therapeutic | Aneurysm | - | 10813312|18592134 | - | |
| 1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol | C435044 | - | Aneurysm | MMP1 | 5.23 | 21742783 | CTD |
| 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester | C070379 | - | Aneurysm | MMP1 | 4.1 | 21742783 | CTD |
| 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one | C569107 | - | Aneurysm | MMP1 | 4.66 | 21742783 | CTD |
| 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt | D014013 | - | Aneurysm | MMP1 | 4.48 | 21742783 | CTD |
| 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin | C540360 | - | Aneurysm | MMP1 | 5.77 | 21742783 | CTD |
| 15-deoxy-delta(12,14)-prostaglandin J2 | C097240 | - | Aneurysm | MMP1 | 4.16 | 21742783 | CTD |
| 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione | C060229 | - | Aneurysm | MMP1 | 4.43 | 21742783 | CTD |
| 2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester | C548651 | - | Aneurysm | MMP1 | 3.28 | 21742783 | CTD |