Cardiovascular Disease Atlas
Data release 1.0
| Disease | Aortic dissection |
|---|---|
| CVD Atlas ID | CVDD000108 |
| MeSH ID | D000784 |
| Ontology ID | NCIT:C50461 |
| Description [MeSH] | A tear in the inner layer of the AORTA leading to interstitial HEMORRHAGE, and splitting (dissecting) of the aortic TUNICA MEDIA layer. It typically begins with a tear in the TUNICA INTIMA layer. |
| Dataset | Reported disease | Tissue/cell type | Omics | Data accession |
|---|---|---|---|---|
| CVDS000025 | Aortic dissection | Aorta | Transcriptomics | GSE147026 |
| CVDS000026 | Aortic dissection | Aorta | Transcriptomics | GSE153434 |
| CVDS000042 | Aortic dissection | Aorta | Transcriptomics | GSE190635 |
| CVDS000046 | Aortic dissection | Aorta | Epigenomics | GSE202047 |
| CVDS000058 | Aortic dissection | Aorta | Transcriptomics | GSE52093 |
| Variant | Gene | Beta | Standard error | P value | Odds ratio | Study | Ancestry | Link |
|---|
| Gene | Tissue | Best coloc SNP | GWAS risk SNP | SNP.PP.H4 | PP.H4.abf | Ancestry | Dataset |
|---|
| Variant | Gene | Description | PMID |
|---|---|---|---|
| No data available in table | |||
| Variant | Pre miRNA | Region | Mature miRNA |
ΔG
|
Predict
| PMID |
|---|---|---|---|---|---|---|
| No data available in table | ||||||
| SNP | Reported disease | Gene | Description | PMID |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Tissue/cell type | Gene | Reported disease | Alteration | log2FC | P value | Adjusted P value | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Tissue/cell type | Gene | Reported disease | Mapped disease | log2FC | P value | Adjusted P value | Method | Dataset |
|---|
| Gene | Gene type | Species | Reported disease | Score | PMID | Gene link |
|---|---|---|---|---|---|---|
| No data available in table | ||||||
| Reported disease | Tissue | Gene | Effect size | P value | Method | Publication | PMID | Gene link |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| Ischemic cardiomyopathy | FLNC | Homo sapiens | Furthermore, we demonstrated that splicing of 4 key sarcomere genes, cardiac troponin T (TNNT2), cardiac troponin I (TNNI3), myosin heavy chain 7 (MYH7), and filamin C, gamma (FLNC), was significantly altered in ischemic cardiomyopathy and in dilated cardiomyopathy and aortic stenosis | 20124440 |
| Ischemic cardiomyopathy | MYH7 | Homo sapiens | Furthermore, we demonstrated that splicing of 4 key sarcomere genes, cardiac troponin T (TNNT2), cardiac troponin I (TNNI3), myosin heavy chain 7 (MYH7), and filamin C, gamma (FLNC), was significantly altered in ischemic cardiomyopathy and in dilated cardiomyopathy and aortic stenosis | 20124440 |
| Ischemic cardiomyopathy | TNNI3 | Homo sapiens | Furthermore, we demonstrated that splicing of 4 key sarcomere genes, cardiac troponin T (TNNT2), cardiac troponin I (TNNI3), myosin heavy chain 7 (MYH7), and filamin C, gamma (FLNC), was significantly altered in ischemic cardiomyopathy and in dilated cardiomyopathy and aortic stenosis | 20124440 |
| Ischemic cardiomyopathy | TNNT2 | Homo sapiens | Furthermore, we demonstrated that splicing of 4 key sarcomere genes, cardiac troponin T (TNNT2), cardiac troponin I (TNNI3), myosin heavy chain 7 (MYH7), and filamin C, gamma (FLNC), was significantly altered in ischemic cardiomyopathy and in dilated cardiomyopathy and aortic stenosis | 20124440 |
| Name | Gene | Relation to gene | Tissue | Reported disease | Delta beta | P value | Adjusted P value | Dataset | GEO accession |
|---|
| Name | Gene | Relation to gene | Reported disease | Delta beta | P value | Adjusted P value | Tissue | PMID |
|---|
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Gene | Protein | Average log2FC | P value | Dataset |
|---|---|---|---|---|
| A0A024QYX3 | 1.01 | 0.0127 | CVDS000501 | |
| A0A024QZ34 | 2.35 | 0.000134 | CVDS000501 | |
| A0A024QZJ6 | -4.22 | 0.000175 | CVDS000501 | |
| A0A024QZS1 | -1.01 | 0.00423 | CVDS000501 | |
| A0A024R1S8 | 1.05 | 0.0164 | CVDS000501 | |
| A0A024R3C3 | -1.09 | 0.0253 | CVDS000501 | |
| A0A024R3E3 | 1.67 | 0.000117 | CVDS000501 | |
| A0A024R3U8 | -1.1 | 0.0132 | CVDS000501 | |
| A0A024R5Q4 | 2.39 | 5.33e-06 | CVDS000501 | |
| A0A024R6B5 | 2.52 | 3.4e-05 | CVDS000501 |
| Metabolite | VIP | Dataset |
|---|---|---|
| 5-Hydroxyindoleacetic acid | 1.367 | CVDS000488 |
| Adenosine | 1.292 | CVDS000486 |
| Adenosine | 1.208 | CVDS000491 |
| Anserine | 1.009 | CVDS000492 |
| Anserine | 1.27 | CVDS000491 |
| ATP | 1.04 | CVDS000489 |
| ATP | 1.165 | CVDS000487 |
| Biotin | 1.263 | CVDS000489 |
| Biotin | 2.647 | CVDS000487 |
| Biotin | 1.144 | CVDS000493 |
| Chemical name | Chemical ID | Direct evidence | Reported disease | Inference gene | Inference score | #PMIDs | Gene link |
|---|