Trait

Name	Hypercholesterolemia
CVD Atlas ID	CVDT000011
Ontology ID	NCIT:C37967

Search:

Gene	Score
APOB	0.77294
LPL	0.77294
RASIP1	0.77294
APOE	0.77294
IZUMO1	0.77294

Showing 1 to 5 of 836 entries

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Ancestry

Search:

Dataset	Reported trait	Ancestry	Title	PMID	Data source
CVDS000130	Triglyceride levels	European	Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations.	28887542	GCST005073
CVDS000152	Triglyceride levels	Mixed ancestry	Genetic analyses of diverse populations improves discovery for complex traits.	31217584	GCST008046
CVDS000156	Total triglycerides levels	European	Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.	27005778	GCST003664
CVDS000160	Triglyceride levels	Mixed ancestry	Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.	28334899	GCST004237
CVDS000193	Triglycerides	Mixed ancestry	A large electronic-health-record-based genome-wide study of serum lipids.	29507422	GCST007142
CVDS000225	Triglyceride levels (UKB data field 30870)	European	Computationally efficient whole-genome regression for quantitative and binary traits.	34017140	GCST90014014
CVDS000243	Triglycerides	East Asian	A cross-population atlas of genetic associations for 220 human phenotypes.	34594039	GCST90018755
CVDS000258	Triglycerides	Mixed ancestry	A cross-population atlas of genetic associations for 220 human phenotypes.	34594039	GCST90018975
CVDS000262	Triglyceride levels	Mixed ancestry	Genetics of 35 blood and urine biomarkers in the UK Biobank.	33462484	GCST90019523
CVDS000266	Total Triacylglycerol levels	European	Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.	35668104	GCST90024605

Showing 1 to 10 of 26 entries

Ancestry

Search:

SNP	Reported trait	Ancestry	Beta	Standard error	Odds ratio	P value	Dataset
rs1000237	Concentration of medium VLDL particles (UKB data field 23502)	European	-0.0284	0.00494	0.972	9.07e-09	CVDS000448
rs1000237	Concentration of large VLDL particles (UKB data field 23495)	European	-0.0271	0.0048	0.973	1.53e-08	CVDS000447
rs1000237	Concentration of very large VLDL particles	European	-0.0305	0.00415	0.97	2.1e-13	CVDS000370
rs1000237	Concentration of VLDL particles	European	-0.0317	0.00428	0.969	1.4e-13	CVDS000367
rs1000237	VLDL cholesterol levels	European	-0.0326	0.00431	0.968	4.1e-14	CVDS000366
rs1000237	Concentration of small VLDL particles	European	-0.0295	0.00425	0.971	4e-12	CVDS000361
rs1000237	Concentration of medium VLDL particles	European	-0.0361	0.00431	0.965	5.1e-17	CVDS000358
rs1000237	Concentration of large VLDL particles	European	-0.0332	0.00417	0.967	1.7e-15	CVDS000352
rs10007119	Concentration of large VLDL particles (UKB data field 23495)	European	0.0257	0.00465	1.03	3.15e-08	CVDS000447
rs10007119	Concentration of very large VLDL particles	European	0.0237	0.00402	1.02	3.6e-09	CVDS000370

Showing 1 to 10 of 109,788 entries

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Tissue

Ancestry

Top genes selected

by median of PP.H4

by number of datasets

Gene	Tissue	Ancestry	Best coloc SNP	GWAS risk SNP	SNP.PP.H4	PP.H4.abf	Dataset

This panel displays associations of genes with this disease integrated from other databases.

Search:

Reported trait	Tissue	Gene	Effect size	P value	Method	Publication	PMID	Gene link
No data available in table

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Basic information

Gene priorization

GWAS dataset

GWAS significant SNP

Colocalization analysis

Trait-gene association