| URL: | http://neotcrdb.bioxai.cn/ |
| Full name: | neoantigen-specific TCR sequences |
| Description: | NeoTCR is an immunoinformatic database of T-cell receptor (TCR) sequences with neoantigen specificities. The primary goal of NeoTCR is to facilitate access to existing information on neoantigen-specific TCRs, such as the neoepitope that it recognizes and binds, the relating somatic mutation, the HLA contexts, and so on. NeoTCR allows for fuzzy or accurate database searching based on different criteria. Besides, NeoTCR also provides useful web-based tools for comprehensive analysis of TCR sequencing data that users upload. |
| Year founded: | 2022 |
| Last update: | 2024-02-03 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Nankai University |
| Address: | Centre for Bioinformatics and Intelligent Medicine, Nankai University, Tianjin, 300350, China |
| City: | Tianjin |
| Province/State: | Tianjin |
| Country/Region: | China |
| Contact name (PI/Team): | Jian Liu |
| Contact email (PI/Helpdesk): | jianliu@nankai.edu.cn |
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NeoTCR: an immunoinformatic database of experimentally-supported functional neoantigen-specific TCR sequences. [PMID: 39436255]
Neoantigen-based immunotherapy has demonstrated long-lasting antitumor activity. The recognition of neoantigens by T cell receptors (TCRs) is considered a trigger for antitumor responses. Due to the overwhelming number of TCR repertoires in the human genome, pinpointing neoantigen-specific TCRs is a formidable challenge. Recent studies have identified a number of functional neoantigen-specific TCRs, but the corresponding information is scattered across published literature and is difficult to retrieve. To improve access to these data, we developed an immunoinformatic database (NeoTCR) containing a unified description of publicly available neoantigen-specific TCR sequences, as well as relevant information on targeted neoantigens, from experimentally supported studies across 18 cancer subtypes. A user-friendly web interface allows interactive browsing and running of complex database queries. To facilitate rapid identification of neoantigen-specific TCRs from raw sequencing data, NeoTCR offers a one-stop analysis for annotation and visualization of TCR clonotypes, discovery of existing neoantigen-specific TCRs, and exclusion of bystander viral-associated TCRs. NeoTCR represents a unique tool to expedite future studies of neoantigen-specific TCRs and the development of neoantigen-based immunotherapy. NeoTCR is available at http://neotcrdb.bioaimed.com/ and https://github.com/lyotvincent/NeoTCR. |