| URL: | http://warta.bio.psu.edu/DED/ |
| Full name: | Database of Evolutionary Distances |
| Description: | DED is a large database of homologous sequence alignments with good estimates of evolutionary distances for molecular evolutionary studies and phylogenetic research. |
| Year founded: | 2005 |
| Last update: | |
| Version: | |
| Accessibility: |
Unaccessible
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| Country/Region: | United States |
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| University/Institution: | University Park |
| Address: | Pennsylvania State University, University Park, PA 16802, USA |
| City: | University Park |
| Province/State: | PA |
| Country/Region: | United States |
| Contact name (PI/Team): | Wojciech Makałowski |
| Contact email (PI/Helpdesk): | wojtek@psu.edu |
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DED: Database of Evolutionary Distances. [PMID: 15608234]
A large database of homologous sequence alignments with good estimates of evolutionary distances can be a valuable resource for molecular evolutionary studies and phylogenetic research in particular. We recently created a database containing 159,921 transcripts from human, mouse, rat, zebrafish and fugu species. Approximately 1,000 homology groups were identified with the help of Ensembl homology evidence. At the macro-level, the database allows us to answer queries of the form: 1. What is the average k-distance between 5' untranslated regions of human and mouse? 2. List the 10 groups with the highest K(a)/K(s) ratio between mouse and rat. 3. List all identical proteins between human and rat. Researchers interested in specific proteins can use a simple web interface to retrieve the homology groups of interest, examine all pairwise distances between members of the group and study the conservation of exon-intron gene structures using a graphical interface. The database is available at http://warta.bio.psu.edu/DED/. |