| URL: | http://microrna.osu.edu/.UCbase4 |
| Full name: | Ultraconserved sequences data and miRNA function |
| Description: | UCbase & miRfunc is a database of ultraconserved sequences and microRNA function. |
| Year founded: | 2009 |
| Last update: | 2008-10-22 |
| Version: | v1.0 |
| Accessibility: |
Accessible
|
| Country/Region: | United States |
| Data type: | |
| Data object: |
NA
|
| Database category: | |
| Major species: |
NA
|
| Keywords: |
| University/Institution: | Ohio State University |
| Address: | Columbus, OH 43210 USA |
| City: | Columbus |
| Province/State: | OH |
| Country/Region: | United States |
| Contact name (PI/Team): | Carlo Maria Croce |
| Contact email (PI/Helpdesk): | carlo.croce@osumc.edu |
|
UCbase & miRfunc: a database of ultraconserved sequences and microRNA function. [PMID: 18945703]
Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4. |