| URL: | http://erop.inbi.ras.ru |
| Full name: | Endogenous Regulatory OligoPeptide knowledgebase |
| Description: | EROP-Moscow is a curated oligopeptide (2-50 amino acid residues) sequence database which strives to provide a high level of annotations (such as descriptions of the structure of an oligopeptide, its source and function, post-translational modifications, etc.). |
| Year founded: | 2006 |
| Last update: | 2018-10-05 |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | Russian Federation |
| University/Institution: | Russian Academy of Sciences |
| Address: | A.N. Bach Institute of Biochemistry, Russian Academy of Sciences 33 Leninsky prosp., Moscow 119071, Russian Federation |
| City: | Moscow |
| Province/State: | |
| Country/Region: | Russian Federation |
| Contact name (PI/Team): | Alexander A. Zamyatnin |
| Contact email (PI/Helpdesk): | aaz@inbi.ras.ru |
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Structural-functional diversity of the natural oligopeptides. [PMID: 28974379]
Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of many oligopeptides have been identified from >2000 organisms representing all the biological kingdoms. We have considered a number of mathematical (sequence length), chemical, physical, and biological features of an array of natural oligopeptides on the basis of the oligopeptide EROP-Moscow database (http://erop.inbi.ras.ru, 15,351 entries) data. There is the substantial difference of these substances from polypeptide molecules of proteins according to their physicochemical characteristics. These characteristics may be critical for understanding the molecular mechanisms of the action of oligopeptides that lead to the development of physiological effects. |
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The EROP-Moscow oligopeptide database. [PMID: 16381860]
Natural oligopeptides may regulate nearly all vital processes. To date, the chemical structures of nearly 6000 oligopeptides have been identified from >1000 organisms representing all the biological kingdoms. We have compiled the known physical, chemical and biological properties of these oligopeptides--whether synthesized on ribosomes or by non-ribosomal enzymes--and have constructed an internet-accessible database, EROP-Moscow (Endogenous Regulatory OligoPeptides), which resides at http://erop.inbi.ras.ru. This database enables users to perform rapid searches via many key features of the oligopeptides, and to carry out statistical analysis of all the available information. The database lists only those oligopeptides whose chemical structures have been completely determined (directly or by translation from nucleotide sequences). It provides extensive links with the Swiss-Prot-TrEMBL peptide-protein database, as well as with the PubMed biomedical bibliographic database. EROP-Moscow also contains data on many oligopeptides that are absent from other convenient databases, and is designed for extended use in classifying new natural oligopeptides and for production of novel peptide pharmaceuticals. |