| URL: | http://ppi.bioinfo.asia.edu.tw/FARE-CAFE/ |
| Full name: | Database of Functional and Regulatory Elements of Cancer-Associated Fusion Events |
| Description: | FARE-CAFE is a database of functional and regulatory elements of cancer-associated fusion events. It is a database with the combination of the cancer related chromosomal translation events, fusion genes, domains, domain-domain interactions (DDI), protein-protein interactions (PPI), transcription factors(TF) and miRNAs collectively with the consequent experimental information. |
| Year founded: | 2015 |
| Last update: | 2015-09-16 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Asia University |
| Address: | Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan |
| City: | Taichung |
| Province/State: | Taiwan |
| Country/Region: | China |
| Contact name (PI/Team): | Ka-LoK Ng |
| Contact email (PI/Helpdesk): | ppiddi@gmail.com |
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FARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events. [PMID: 26384373]
Chromosomal translocation (CT) is of enormous clinical interest because this disorder is associated with various major solid tumors and leukemia. A tumor-specific fusion gene event may occur when a translocation joins two separate genes. Currently, various CT databases provide information about fusion genes and their genomic elements. However, no database of the roles of fusion genes, in terms of essential functional and regulatory elements in oncogenesis, is available. FARE-CAFE is a unique combination of CTs, fusion proteins, protein domains, domain-domain interactions, protein-protein interactions, transcription factors and microRNAs, with subsequent experimental information, which cannot be found in any other CT database. Genomic DNA information including, for example, manually collected exact locations of the first and second break points, sequences and karyotypes of fusion genes are included. FARE-CAFE will substantially facilitate the cancer biologist's mission of elucidating the pathogenesis of various types of cancer. This database will ultimately help to develop 'novel' therapeutic approaches. Database URL: http://ppi.bioinfo.asia.edu.tw/FARE-CAFE. © The Author(s) 2015. Published by Oxford University Press. |