| URL: | http://sideeffects.embl.de/ |
| Full name: | Side Effect Resource |
| Description: | SIDER contains information on marketed medicines and their recorded adverse drug reactions. The information is extracted from public documents and package inserts. The available information include side effect frequency, drug and side effect classifications as well as links to further information, for example drug–target relations. |
| Year founded: | 2010 |
| Last update: | 2015-10-21 |
| Version: | v4.1 |
| Accessibility: |
Accessible
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| Country/Region: | Germany |
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| University/Institution: | European Molecular Biology Laboratory |
| Address: | Meyerhofstrasse 1, 69117 Heidelberg, Germany |
| City: | Heidelberg |
| Province/State: | |
| Country/Region: | Germany |
| Contact name (PI/Team): | Peer Bork |
| Contact email (PI/Helpdesk): | bork@embl.de |
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The SIDER database of drugs and side effects. [PMID: 26481350]
Unwanted side effects of drugs are a burden on patients and a severe impediment in the development of new drugs. At the same time, adverse drug reactions (ADRs) recorded during clinical trials are an important source of human phenotypic data. It is therefore essential to combine data on drugs, targets and side effects into a more complete picture of the therapeutic mechanism of actions of drugs and the ways in which they cause adverse reactions. To this end, we have created the SIDER ('Side Effect Resource', http://sideeffects.embl.de) database of drugs and ADRs. The current release, SIDER 4, contains data on 1430 drugs, 5880 ADRs and 140 064 drug-ADR pairs, which is an increase of 40% compared to the previous version. For more fine-grained analyses, we extracted the frequency with which side effects occur from the package inserts. This information is available for 39% of drug-ADR pairs, 19% of which can be compared to the frequency under placebo treatment. SIDER furthermore contains a data set of drug indications, extracted from the package inserts using Natural Language Processing. These drug indications are used to reduce the rate of false positives by identifying medical terms that do not correspond to ADRs. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. |
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A side effect resource to capture phenotypic effects of drugs. [PMID: 20087340]
The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de. |