| URL: | http://irndb.org/ |
| Full name: | database of immunologically relevant non-coding RNAs |
| Description: | IRNdb is a database that combines microRNA, PIWI-interacting RNAs, and long non-coding RNA information with immunologically relevant target genes. IRNdb contains information for mouse as it is often used as a model organism for immunological research purposes. Currently, IRNdb combines 1122 miRNAs, 319 piRNAs, 163 lncRNAs and 5514 immunologically relevant mouse targets. |
| Year founded: | 2016 |
| Last update: | 2018 |
| Version: | v1.5.8 |
| Accessibility: |
Accessible
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| Country/Region: | New Zealand |
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| University/Institution: | Massey University |
| Address: | Institute of Natural and Mathematical Sciences |
| City: | Albany |
| Province/State: | Auckland |
| Country/Region: | New Zealand |
| Contact name (PI/Team): | Sebastian Schmeier |
| Contact email (PI/Helpdesk): | s.schmeier@massey.ac.nz |
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IRNdb: the database of immunologically relevant non-coding RNAs. [PMID: 31414702]
MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified as a critical regulatory mechanism in the immune system. Despite the great efforts made to discover and characterize ncRNAs, the functional role for most remains unknown. To facilitate discoveries in ncRNA regulation of immune system-related processes, we developed the database of immunologically relevant ncRNAs and target genes (IRNdb). We integrated mouse data on predicted and experimentally supported ncRNA-target interactions, ncRNA and gene annotations, biological pathways and processes and experimental data in a uniform format with a user-friendly web interface. The current version of IRNdb documents 12 930 experimentally supported miRNA-target interactions between 724 miRNAs and 2427 immune-related mouse targets. In addition, we recorded 22 453 lncRNA-immune target and 377 PIWI-interacting RNA-immune target interactions. IRNdb is a comprehensive searchable data repository which will be of help in studying the role of ncRNAs in the immune system. Database URL:http://irndb.org. |