| URL: | http://songyanglab.sysu.edu.cn/ccsi |
| Full name: | Chromatin–Chromatin Spatial Interaction |
| Description: | CCSI integrats and annotating 91 sets of chromatin interaction data derived from published literature, UCSC database and NCBI GEO database, resulting in a total of 3 017 962 pairwise interactions (false discovery rate < 0.05), covering human, mouse and yeast. |
| Year founded: | 2016 |
| Last update: | 2016-02-11 |
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| Accessibility: |
Unaccessible
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| Country/Region: | China |
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| University/Institution: | Sun Yat-Sen University |
| Address: | Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory of Biocontrol, School of Life Sciences |
| City: | Zhongshan |
| Province/State: | Guangdong |
| Country/Region: | China |
| Contact name (PI/Team): | Yuanyan Xiong |
| Contact email (PI/Helpdesk): | xyyan@mail.sysu.edu.cn |
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CCSI: a database providing chromatin-chromatin spatial interaction information. [PMID: 26868054]
Distal regulatory elements have been shown to regulate gene transcription through spatial interactions, and single nucleotide polymorphisms (SNPs) are linked with distal gene expression by spatial proximity, which helps to explain the causal role of disease-associated SNPs in non-coding region. Therefore, studies on spatial interactions between chromatin have created a new avenue for elucidating the mechanism of transcriptional regulation in disease pathogenesis. Recently, a growing number of chromatin interactions have been revealed by means of 3C, 4C, 5C, ChIA-PET and Hi-C technologies. To interpret and utilize these interactions, we constructed chromatin-chromatin spatial interaction (CCSI) database by integrating and annotating 91 sets of chromatin interaction data derived from published literature, UCSC database and NCBI GEO database, resulting in a total of 3,017,962 pairwise interactions (false discovery rate? |