| URL: | http://kaliumdb.org/ |
| Full name: | Kalium |
| Description: | Kalium is a comprehensive database of polypeptide ligands of potassium channels. This database is an open-access resource, and all information presented here is manually curated. Kalium provides easy access to pages of other databases of interest, such as UniProt taxonomic database, PubMed, UniProt, and PDB. |
| Year founded: | 2016 |
| Last update: | 2018-09-01 |
| Version: | 2.0 |
| Accessibility: |
Accessible
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| Country/Region: | Russian Federation |
| University/Institution: | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences |
| Address: | 117997, Russian Federation, Moscow, GSP-7, Ulitsa Miklukho-Maklaya, 16/10 |
| City: | Moscow |
| Province/State: | |
| Country/Region: | Russian Federation |
| Contact name (PI/Team): | Alexander A. Vassilevski |
| Contact email (PI/Helpdesk): | avas@ibch.ru |
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Kalium 3.0 is a comprehensive depository of natural, artificial, and labeled polypeptides acting on potassium channels. [PMID: 37682529]
Here, we introduce the third release of Kalium database (http://kaliumdb.org/), a manually curated comprehensive depository that accumulates data on polypeptide ligands of potassium channels. The major goal of this amplitudinous update is to summarize findings for natural polypeptide ligands of K channels, as well as data for the artificial derivatives of these substances obtained over the decades of exploration. We manually analyzed more than 700 original manuscripts and systematized the information on mutagenesis, production of radio- and fluorescently labeled derivatives, and the molecular pharmacology of K channel ligands. As a result, data on more than 1200 substances were processed and added enriching the database content fivefold. We also included the electrophysiological data obtained on the understudied and neglected K channels including the heteromeric and concatenated channels. We associated target channels in Kalium with corresponding entries in the official database of the International Union of Basic and Clinical Pharmacology. Kalium was supplemented with an adaptive Statistics page, where users are able to obtain actual data output. Several other improvements were introduced, such as a color code to distinguish the range of ligand activity concentrations and advanced tools for filtration and sorting. Kalium is a fully open-access database, crosslinked to other databases of interest. It can be utilized as a convenient resource containing ample up-to-date information about polypeptide ligands of K channels. |
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Kalium: a database of potassium channel toxins from scorpion venom. [PMID: 27087309]
Kalium (http://kaliumdb.org/) is a manually curated database that accumulates data on potassium channel toxins purified from scorpion venom (KTx). This database is an open-access resource, and provides easy access to pages of other databases of interest, such as UniProt, PDB, NCBI Taxonomy Browser, and PubMed. General achievements of Kalium are a strict and easy regulation of KTx classification based on the unified nomenclature supported by researchers in the field, removal of peptides with partial sequence and entries supported by transcriptomic information only, classification of ?-family toxins, and addition of a novel ?-family. Molecules presented in the database can be processed by the Clustal Omega server using a one-click option. Molecular masses of mature peptides are calculated and available activity data are compiled for all KTx. We believe that Kalium is not only of high interest to professional toxinologists, but also of general utility to the scientific community.Database URL:http://kaliumdb.org/. © The Author(s) 2016. Published by Oxford University Press. |