| URL: | http://eul1db.unice.fr/ |
| Full name: | European database of L1HS retrotransposon insertions in humans |
| Description: | euL1db provides a curated and comprehensive summary of L1-HS insertion polymorphisms identified in healthy or pathological human samples and published in peer-reviewed journals. It will help understanding the link between L1 retrotransposon insertion polymorphisms and phenotype or disease. |
| Year founded: | 2015 |
| Last update: | 20/03/2018 |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | France |
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| University/Institution: | Institute for Research on Cancer and Aging of Nice |
| Address: | INSERM,U1081,Institute for Research on Cancer and Aging of Nice (IRCAN),F-06100 Nice,France |
| City: | Nice |
| Province/State: | |
| Country/Region: | France |
| Contact name (PI/Team): | Gael Cristofari |
| Contact email (PI/Helpdesk): | Gael.Cristofari@unice.fr |
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euL1db: the European database of L1HS retrotransposon insertions in humans. [PMID: 25352549]
Retrotransposons account for almost half of our genome. They are mobile genetics elements-also known as jumping genes--but only the L1HS subfamily of Long Interspersed Nuclear Elements (LINEs) has retained the ability to jump autonomously in modern humans. Their mobilization in germline--but also some somatic tissues--contributes to human genetic diversity and to diseases, such as cancer. Here, we present euL1db, the European database of L1HS retrotransposon insertions in humans (available at http://euL1db.unice.fr). euL1db provides a curated and comprehensive summary of L1HS insertion polymorphisms identified in healthy or pathological human samples and published in peer-reviewed journals. A key feature of euL1db is its sample--wise organization. Hence L1HS insertion polymorphisms are connected to samples, individuals, families and clinical conditions. The current version of euL1db centralizes results obtained in 32 studies. It contains >900 samples, >140,000 sample-wise insertions and almost 9000 distinct merged insertions. euL1db will help understanding the link between L1 retrotransposon insertion polymorphisms and phenotype or disease. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. |