| URL: | http://ucbase.unimore.it. |
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| Description: | Home UC Data Mining Related Works Contact Us Welcome to the UCbase 2.0 Ultraconserved elements (UCRs), that were first described by Bejerano et al. in 2004 (Science. 2004;304:1321-5), are highly conserved genome regions that share 100% identity among human, mouse and rat. UCRs are 481 sequences longer than 200 bases. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs. |
| Year founded: | 2014 |
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Accessible
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| Country/Region: | Italy |
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| University/Institution: | University of Modena and Reggio Emilia |
| Address: | Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100, Modena, Italy |
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| Country/Region: | Italy |
| Contact name (PI/Team): | Taccioli C |
| Contact email (PI/Helpdesk): | cristian.taccioli@unimore.it |
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UCbase 2.0: ultraconserved sequences database (2014 update). [PMID: 24951797]
UCbase 2.0 (http://ucbase.unimore.it) is an update, extension and evolution of UCbase, a Web tool dedicated to the analysis of ultraconserved sequences (UCRs). UCRs are 481 sequences >200 bases sharing 100% identity among human, mouse and rat genomes. They are frequently located in genomic regions known to be involved in cancer or differentially expressed in human leukemias and carcinomas. UCbase 2.0 is a platform-independent Web resource that includes the updated version of the human genome annotation (hg19), information linking disorders to chromosomal coordinates based on the Systematized Nomenclature of Medicine classification, a query tool to search for Single Nucleotide Polymorphisms (SNPs) and a new text box to directly interrogate the database using a MySQL interface. To facilitate the interactive visual interpretation of UCR chromosomal positioning, UCbase 2.0 now includes a graph visualization interface directly linked to UCSC genome browser. Database URL: http://ucbase.unimore.it. |