| URL: | http://www.synapse.org/cutaneousNF |
| Full name: | Children tumor foundation biobank |
| Description: | This project includes high-throughput data from 11 different patient tumors and matched blood samples. These data are then compared with one another to assess the distinct landscape of cutaneous NF for each patient. |
| Year founded: | 2017 |
| Last update: | 2018 |
| Version: | |
| Accessibility: |
Accessible
|
| Country/Region: | United States |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | Children’s Tumour Foundation |
| Address: | Children’s Tumour Foundation, New York, New York 10005, USA |
| City: | New York |
| Province/State: | |
| Country/Region: | United States |
| Contact name (PI/Team): | Annette Bakker |
| Contact email (PI/Helpdesk): | abakker@ctf.org |
|
A high-throughput molecular data resource for cutaneous neurofibromas. [PMID: 28398289]
Neurofibromatosis type 1 (NF1) is a genetic disorder with a range of clinical manifestations such as widespread growth of benign tumours called neurofibromas, pain, learning disorders, bone deformities, vascular abnormalities and even malignant tumours. With the establishment of the Children's Tumour Foundation biobank, neurofibroma samples can now be collected directly from patients to be analysed by the larger scientific community. This work describes a pilot study to characterize one class of neurofibroma, cutaneous neurofibromas, by molecularly profiling of ~40 cutaneous neurofibromas collected from 11 individual patients. Data collected from each tumour includes (1) SNP Arrays, (2) Whole genome sequencing (WGS) and (3) RNA-Sequencing. These data are now freely available for further analysis at http://www.synapse.org/cutaneousNF. |