| URL: | http://crdd.osdd.net/raghava/mtbveb |
| Full name: | A web portal for M. tuberculosis vaccines |
| Description: | MtbVeb is a web-based platform developed for designing vaccines against existing and emerging strains of mycobacterium tuberculosis. This includes drug resistant and extreme drug resistant M.Tb strains. It also allow users to design vaccines against M.tb using all three appraoches (strain, antigen and epitope based vaccines). The current version of portal maintain comprehensive genomic information about 59 mycobacterium strains that includes 4 vaccine strains, 6 clinical isolates, drug resistant strains. In this study, we provides comprehensive information in the term of antigenicity of about 178 potential vaccine candidates in each of the strain. |
| Year founded: | 2016 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | India |
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| University/Institution: | Institute of Microbial Technology |
| Address: | Sector 39-A, Chandigarh-160036, India |
| City: | Chandigarh |
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| Country/Region: | India |
| Contact name (PI/Team): | Gajendra P. S. Raghava |
| Contact email (PI/Helpdesk): | raghava@iiitd.ac.in |
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A Web-Based Platform for Designing Vaccines against Existing and Emerging Strains of Mycobacterium tuberculosis. [PMID: 27096425]
Development of an effective vaccine against drug-resistant Mycobacterium tuberculosis (Mtb) is crucial for saving millions of premature deaths every year due to tuberculosis. This paper describes a web portal developed for assisting researchers in designing vaccines against emerging Mtb strains using traditional and modern approaches. Firstly, we annotated 59 genomes of Mycobacterium species to understand similarity/dissimilarity between tuberculoid, non-tuberculoid and vaccine strains at genome level. Secondly, antigen-based vaccine candidates have been predicted in each Mtb strain. Thirdly, epitopes-based vaccine candidates were predicted/discovered in above antigen-based vaccine candidates that can stimulate all arms of immune system. Finally, a database of predicted vaccine candidates at epitopes as well at antigen level has been developed for above strains. In order to design vaccine against a newly sequenced genome of Mtb strain, server integrates three modules for identification of strain-, antigen-, epitope-specific vaccine candidates. We observed that 103,522 unique peptides (9mers) had the potential to induce an antibody response and/or promiscuous binder to MHC alleles and/or have the capability to stimulate T lymphocytes. In summary, this web-portal will be useful for researchers working on designing vaccines against Mtb including drug-resistant strains. |