| URL: | http://pcs-db.fr |
| Full name: | protein chemical synthesis database |
| Description: | protein chemical synthesis (PCS) database (http://pcs-db.fr) was created by collecting a set of relevant data from more than 450 publications covering the period 1994-2017. A preliminary account of what this database tells us is presented in this report. |
| Year founded: | 2017 |
| Last update: | 2017 |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | France |
| Data type: | |
| Data object: |
NA
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| Database category: | |
| Major species: |
NA
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| Keywords: |
| University/Institution: | Scientific Research National Center |
| Address: | Univ. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 – M3T – Mechanisms of Tumorigenesis and Target Therapies, F-59000 Lille, France contact@pcs-db.fr. |
| City: | Lille |
| Province/State: | |
| Country/Region: | France |
| Contact name (PI/Team): | Oleg Melnyk |
| Contact email (PI/Helpdesk): | oleg.melnyk@ibl.cnrs.fr |
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A statistical view of protein chemical synthesis using NCL and extended methodologies. [PMID: 28578993]
Native chemical ligation and extended methodologies are the most popular chemoselective reactions for protein chemical synthesis. Their combination with desulfurization techniques can give access to small or challenging proteins that are exploited in a large variety of research areas. In this report, we have conducted a statistical review of their use for protein chemical synthesis in order to provide a flavor of the recent trends and identify the most popular chemical tools used by protein chemists. To this end, a protein chemical synthesis (PCS) database (http://pcs-db.fr) was created by collecting a set of relevant data from more than 450 publications covering the period 1994-2017. A preliminary account of what this database tells us is presented in this report. |