| URL: | http://bioinfopresidencycollegekolkata.edu.in/antagomirs |
| Full name: | a putative antagomir database |
| Description: | We have developed Antagomir database, based on putative antagomirs-miRNA heterodimers and humiR sequence. Also, a tool has been integrated in this database. The tool accepts a sequence of 20-25 nuleotides and if it finds a match with the existing putative antagomirs in the database then it returns the respective target i.e. humiR ID along with the secondary structure of antagomirs. |
| Year founded: | 2011 |
| Last update: | |
| Version: | |
| Accessibility: |
Unaccessible
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| Country/Region: | India |
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| University/Institution: | Presidency University |
| Address: | DBT-Centre for Bioinformatics, Presidency University, Kolkata – 700073 |
| City: | Kolkata |
| Province/State: | |
| Country/Region: | India |
| Contact name (PI/Team): | Sayak Ganguli |
| Contact email (PI/Helpdesk): | sayakbif@yahoo.com |
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Antagomirbase- a putative antagomir database. [PMID: 21904438]
The accurate prediction of a comprehensive set of messenger putative antagomirs against microRNAs (miRNAs) remains an open problem. In particular, a set of putative antagomirs against human miRNA is predicted in this current version of database. We have developed Antagomir database, based on putative antagomirs-miRNA heterodimers. In this work, the human miRNA dataset was used as template to design putative antagomirs, using GC content and secondary structures as parameters. The algorithm used predicted the free energy of unbound antagomirs. Although in its infancy the development of antagomirs, that can target cell specific genes or families of genes, may pave the way forward for the generation of a new class of therapeutics, to treat complex inflammatory diseases. Future versions need to incorporate further sequences from other mammalian homologues for designing of antagomirs for aid in research. |