Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: http://hcmdb.i-sanger.com/index
Full name: Human Cancer Metastasis Database
Description: HCMDB (Human Cancer Metastasis Database) is an integrated database designed to store and analyze large scale expression data of cancer metastasis. In the current version of HCMDB, it contains 29 cancer types derived from more than 455 experiments. To annotate those potentially metastasis-related genes, a total of 2183 genes (1901 protein-coding genes, 24 long non-coding RNAs and 203 miRNAs) were curated based on more than 7,000 published literatures.
Year founded: 2017
Last update:
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Country/Region: China
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Contact information

University/Institution: East China Normal University
Address: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China
City: Shanghai
Province/State:
Country/Region: China
Contact name (PI/Team): Dong Dong
Contact email (PI/Helpdesk): Ddong.ecnu@gmail.com

Publications

29088455
HCMDB: the human cancer metastasis database. [PMID: 29088455]
Zheng G, Ma Y, Zou Y, Yin A, Li W, Dong D.

Metastasis is the main event leading to death in cancer patients. Over the past decade, high-throughput technologies have provided genome-wide view of transcriptomic changes associated with cancer metastases. Many microarray and RNA sequencing studies have addressed metastases-related expression patterns in various types of cancer, and the number of relevant works continues to increase rapidly. These works have characterized genes that orchestrate the metastatic phenotype of cancer cells. However, these expression data have been deposited in various repositories, and efficiently analyzing these data is still difficult because of the lack of an integrated data mining platform. To facilitate the in-depth analyses of transcriptome data on metastasis, it is quite important to make a comprehensive integration of these metastases-related expression data. Here, we presented a database, HCMDB (the human cancer metastasis database, http://hcmdb.i-sanger.com/index), which is freely accessible to the research community query cross-platform transcriptome data on metastases. HCMDB is developed and maintained as a useful resource for building the systems-biology understanding of metastasis.

Nucleic Acids Res. 2018:46(D1) | 26 Citations (from Europe PMC, 2021-06-19)

Ranking

All databases:
957/5061 (81.11%)
Gene genome and annotation:
314/1350 (76.815%)
Expression:
165/924 (82.251%)
957
Total Rank
26
Citations
8.667
z-index

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Record metadata

Created on: 2018-01-28
Curated by:
Fatima Batool [2018-04-12]
Yang Zhang [2018-01-27]