| URL: | http://zdzlab.einstein.yu.edu/1/hedd.php |
| Full name: | Human Enhancer Disease Database |
| Description: | Enhancers are specialized genomic cis-regulatory elements that play a central role in regulating a wide range of important biological functions and processes, whose impairment could result in disease. HEDD, as a central repository of human enhancers and their disease association, can facilitate genomic research of enhancers and their roles in the human diseases. |
| Year founded: | 2018 |
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| Accessibility: |
Accessible
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| Country/Region: | United States |
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| University/Institution: | Albert Einstein College of Medicine |
| Address: | Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA |
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| Country/Region: | United States |
| Contact name (PI/Team): | Zhengdong D Zhang |
| Contact email (PI/Helpdesk): | zhengdong.zhang@einstein.yu.edu |
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HEDD: Human Enhancer Disease Database. [PMID: 29077884]
Enhancers, as specialized genomic cis-regulatory elements, activate transcription of their target genes and play an important role in pathogenesis of many human complex diseases. Despite recent systematic identification of them in the human genome, currently there is an urgent need for comprehensive annotation databases of human enhancers with a focus on their disease connections. In response, we built the Human Enhancer Disease Database (HEDD) to facilitate studies of enhancers and their potential roles in human complex diseases. HEDD currently provides comprehensive genomic information for ?2.8 million human enhancers identified by ENCODE, FANTOM5 and RoadMap with disease association scores based on enhancer-gene and gene-disease connections. It also provides Web-based analytical tools to visualize enhancer networks and score enhancers given a set of selected genes in a specific gene network. HEDD is freely accessible at http://zdzlab.einstein.yu.edu/1/hedd.php. |