| URL: | http://bioportal.bioontology.org/ontologies/CU-VO |
| Full name: | Venom Ontology |
| Description: | Venoms and venom-derived compounds constitute a rich and largely unexplored source of potentially therapeutic compounds. To facilitate biomedical research, it is necessary to design a robust informatics infrastructure that will allow semantic computation of venom concepts in a standardized, consistent manner. |
| Year founded: | 2016 |
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| Accessibility: |
Accessible
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| Country/Region: | United States |
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| University/Institution: | Columbia University |
| Address: | Departments of Biomedical Informatics, Systems Biology, and Medicine, Columbia University Medical Center, New York, NY |
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| Country/Region: | United States |
| Contact name (PI/Team): | Joseph D. Romano |
| Contact email (PI/Helpdesk): | cumc.columbia.edu |
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Using a Novel Ontology to Inform the Discovery of Therapeutic Peptides from Animal Venoms. [PMID: 27570672]
Venoms and venom-derived compounds constitute a rich and largely unexplored source of potentially therapeutic compounds. To facilitate biomedical research, it is necessary to design a robust informatics infrastructure that will allow semantic computation of venom concepts in a standardized, consistent manner. We have designed an ontology of venom-related concepts - named Venom Ontology - that reuses an existing public data source: UniProt's Tox-Prot database. In addition to describing the ontology and its construction, we have performed three separate case studies demonstrating its utility: (1) An exploration of venom peptide similarity networks within specific genera; (2) A broad overview of the distribution of available data among common taxonomic groups spanning the known tree of life; and (3) An analysis of the distribution of venom complexity across those same taxonomic groups. Venom Ontology is publicly available on BioPortal at http://bioportal.bioontology.org/ontologies/CU-VO. |