| URL: | http://www.nexontology.org |
| Full name: | The Network Extracted Ontology |
| Description: | NeXO is a gene ontology inferred directly from large-scale molecular networks. A gene ontology provides structured knowledge about the cellular components, processes, and functions encoded by genes. While most ontologies – including the highly successful Gene Ontology Database (GO) – are constructed through manual expert curation, NeXO is a data-driven gene ontology inferred directly from ‘omics data. NeXO (The Network Extracted Ontology) uses a principled computational approach which integrates evidence from hundreds of thousands of individual gene and protein interactions to construct a complete hierarchy of cellular components and processes. This data-derived ontology aligns with known biological machinery in the GO Database and also uncovers many new structures. |
| Year founded: | 2014 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | United States |
| Data type: | |
| Data object: |
NA
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| Database category: | |
| Major species: |
NA
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| Keywords: |
| University/Institution: | University of California San Diego |
| Address: | Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA |
| City: | |
| Province/State: | |
| Country/Region: | United States |
| Contact name (PI/Team): | Janusz Dutkowski |
| Contact email (PI/Helpdesk): | janusz@ucsd.edu |
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NeXO Web: the NeXO ontology database and visualization platform. [PMID: 24271398]
The Network-extracted Ontology (NeXO) is a gene ontology inferred directly from large-scale molecular networks. While most ontologies are constructed through manual expert curation, NeXO uses a principled computational approach which integrates evidence from hundreds of thousands of individual gene and protein interactions to construct a global hierarchy of cellular components and processes. Here, we describe the development of the NeXO Web platform (http://www.nexontology.org)-an online database and graphical user interface for visualizing, browsing and performing term enrichment analysis using NeXO and the gene ontology. The platform applies state-of-the-art web technology and visualization techniques to provide an intuitive framework for investigating biological machinery captured by both data-driven and manually curated ontologies. |