| URL: | http://interferome.its.monash.edu.au/interferome/home.jspx |
| Full name: | |
| Description: | INTERFEROME is an upgrade of the original database and contains type I, II and III interferon (IFN) regulated genes, manually curated from publicly available microarray datasets. |
| Year founded: | 2009 |
| Last update: | 2013-01-01 |
| Version: | v2.1 |
| Accessibility: |
Accessible
|
| Country/Region: | Australia |
| Data type: | |
| Data object: |
|
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | Monash University |
| Address: | Centre for Innate Immunity and Infectious Diseases,Monash Institute of Medical Research,Monash University,Clayton,Victoria,Australia |
| City: | Clayton |
| Province/State: | Victoria |
| Country/Region: | Australia |
| Contact name (PI/Team): | Paul J. Hertzog |
| Contact email (PI/Helpdesk): | paul.hertzog@monash.edu |
|
Interferome v2.0: an updated database of annotated interferon-regulated genes. [PMID: 23203888]
Interferome v2.0 (http://interferome.its.monash.edu.au/interferome/) is an update of an earlier version of the Interferome DB published in the 2009 NAR database edition. Vastly improved computational infrastructure now enables more complex and faster queries, and supports more data sets from types I, II and III interferon (IFN)-treated cells, mice or humans. Quantitative, MIAME compliant data are collected, subjected to thorough, standardized, quantitative and statistical analyses and then significant changes in gene expression are uploaded. Comprehensive manual collection of metadata in v2.0 allows flexible, detailed search capacity including the parameters: range of -fold change, IFN type, concentration and time, and cell/tissue type. There is no limit to the number of genes that can be used to search the database in a single query. Secondary analysis such as gene ontology, regulatory factors, chromosomal location or tissue expression plots of IFN-regulated genes (IRGs) can be performed in Interferome v2.0, or data can be downloaded in convenient text formats compatible with common secondary analysis programs. Given the importance of IFN to innate immune responses in infectious, inflammatory diseases and cancer, this upgrade of the Interferome to version 2.0 will facilitate the identification of gene signatures of importance in the pathogenesis of these diseases. |
|
INTERFEROME: the database of interferon regulated genes. [PMID: 18996892]
INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon regulated genes integrates information from high-throughput experiments with annotation, ontology, orthologue sequences from 37 species, tissue expression patterns and gene regulatory information to enable a detailed investigation of the molecular mechanisms underlying IFN biology. INTERFEROME fulfils a need in infection, immunity, development and cancer research by providing computational tools to assist in identifying interferon signatures in gene lists generated by high-throughput expression technologies, and their potential molecular and biological consequences. |