Database Commons
Database Commons

a catalog of worldwide biological databases

Database Profile

General information

URL: http://bcc.ee.cityu.edu.hk/data/EGFR.html
Full name: EGFR Mutant Structural Database
Description: This epidermal growth factor receptor (EGFR) Mutant Structural Database contains 112 EGFR mutant types as well as the binding free energies with reversible tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib.
Year founded: 2015
Last update:
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Country/Region: China

Classification and Labelling

Data type:
DNA
Data object:
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Contact information

University/Institution: University of Hong Kong
Address: Li Ka Sing Faculty of Medicne, University of Hong Kong, Pokfulam, Hong Kong
City: HongKong
Province/State: HongKong
Country/Region: China
Contact name (PI/Team): Victor HF Lee
Contact email (PI/Helpdesk): vhflee@hkucc.hku.hk

Publications

25886721
EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib. [PMID: 25886721]
Ma L, Wang DD, Huang Y, Yan H, Wong MP, Lee VH.

BACKGROUND: Epidermal growth factor receptor (EGFR) mutation-induced drug resistance has caused great difficulties in the treatment of non-small-cell lung cancer (NSCLC). However, structural information is available for just a few EGFR mutants. In this study, we created an EGFR Mutant Structural Database (freely available at http://bcc.ee.cityu.edu.hk/data/EGFR.html ), including the 3D EGFR mutant structures and their corresponding binding free energies with two commonly used inhibitors (gefitinib and erlotinib).
RESULTS: We collected the information of 942 NSCLC patients belonging to 112 mutation types. These mutation types are divided into five groups (insertion, deletion, duplication, modification and substitution), and substitution accounts for 61.61% of the mutation types and 54.14% of all the patients. Among all the 942 patients, 388 cases experienced a mutation at residue site 858 with leucine replaced by arginine (L858R), making it the most common mutation type. Moreover, 36 (32.14%) mutation types occur at exon 19, and 419 (44.48%) patients carried a mutation at exon 21. In this study, we predicted the EGFR mutant structures using Rosetta with the collected mutation types. In addition, Amber was employed to refine the structures followed by calculating the binding free energies of mutant-drug complexes.
CONCLUSIONS: The EGFR Mutant Structural Database provides resources of 3D structures and the binding affinity with inhibitors, which can be used by other researchers to study NSCLC further and by medical doctors as reference for NSCLC treatment.

BMC Bioinformatics. 2015:16() | 10 Citations (from Europe PMC, 2022-08-13)

Ranking

All databases:
3400/5379 (36.81%)
Structure:
456/748 (39.171%)
Genotype phenotype and variation:
484/756 (36.111%)
3400
Total Rank
10
Citations
1.429
z-index

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Record metadata

Created on: 2018-01-28
Curated by:
Lina Ma [2018-04-25]
Alia Rafique [2018-04-04]
Alia Rafique [2018-04-02]