| URL: | http://www.infrafrontier.eu |
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| Description: | INFRAFRONTIER is the European Research Infrastructure for the generation, phenotyping, archiving and distribution of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. |
| Year founded: | 2015 |
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| Accessibility: |
Accessible
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| Country/Region: | Germany |
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| University/Institution: | Ingolstädter Landstraße |
| Address: | INFRAFRONTIER GmbH Ingolstädter Landstraße 1 85764 Neuherberg / München Germany |
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| Country/Region: | Germany |
| Contact name (PI/Team): | Prof. Dr. Martin Hrabé de Angelis & Dr. Daniel Lahne |
| Contact email (PI/Helpdesk): | info@infrafrontier.eu |
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INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community. [PMID: 25414328]
The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques. |