| URL: | https://circinteractome.nia.nih.gov/ |
| Full name: | Circular RNA Interactome |
| Description: | We designed a web tool, CircInteractome, in order to (1) explore potential interactions of circRNAs with RBPs, (2) design specific divergent primers to detect circRNAs, (3) study tissue- and cell-specific circRNAs, (4) identify gene-specific circRNAs, (5) explore potential miRNAs interacting with circRNAs, and (6) design specific siRNAs to silence circRNAs. |
| Year founded: | 2018 |
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| Accessibility: |
Accessible
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| Country/Region: | United States |
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| University/Institution: | National Institute on Aging |
| Address: | Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. |
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| Country/Region: | United States |
| Contact name (PI/Team): | Kotb Abdelmohsen |
| Contact email (PI/Helpdesk): | abdelmohsenk@mail.nih.gov |
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Analysis of Circular RNAs Using the Web Tool CircInteractome. [PMID: 29322439]
Circular RNAs (circRNAs) are generated through nonlinear back splicing, during which the 5' and 3' ends are covalently joined. Consequently, the lack of free ends makes them very stable compared to their counterpart linear RNAs. By selectively interacting with microRNAs and RNA-binding proteins (RBPs), circRNAs have been shown to influence gene expression programs. We designed a web tool, CircInteractome, in order to (1) explore potential interactions of circRNAs with RBPs, (2) design specific divergent primers to detect circRNAs, (3) study tissue- and cell-specific circRNAs, (4) identify gene-specific circRNAs, (5) explore potential miRNAs interacting with circRNAs, and (6) design specific siRNAs to silence circRNAs. Here, we review the CircInteractome tool and explain recent updates to the site. The database is freely accessible at http://circinteractome.nia.nih.gov . |