| URL: | http://www.bioinsilico.org/cgi-bin/CAPSDB/staticHTML/home |
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| Description: | CAPS-DB is a structural classification of helix-cappings or caps compiled from protein structures. |
| Year founded: | 2012 |
| Last update: | 2014-12 |
| Version: | v5.0 |
| Accessibility: |
Accessible
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| Country/Region: | United Kingdom |
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| University/Institution: | University of Leeds |
| Address: | Leeds, LS9 7TF, UK |
| City: | Leeds |
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| Country/Region: | United Kingdom |
| Contact name (PI/Team): | Narcis Fernandez-Fuentes |
| Contact email (PI/Helpdesk): | N.Fernandez-Fuentes@leeds.ac.uk |
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CAPS-DB: a structural classification of helix-capping motifs. [PMID: 22021380]
The regions of the polypeptide chain immediately preceding or following an ?-helix are known as Nt- and Ct cappings, respectively. Cappings play a central role stabilizing ?-helices due to lack of intrahelical hydrogen bonds in the first and last turn. Sequence patterns of amino acid type preferences have been derived for cappings but the structural motifs associated to them are still unclassified. CAPS-DB is a database of clusters of structural patterns of different capping types. The clustering algorithm is based in the geometry and the (?-?)-space conformation of these regions. CAPS-DB is a relational database that allows the user to search, browse, inspect and retrieve structural data associated to cappings. The contents of CAPS-DB might be of interest to a wide range of scientist covering different areas such as protein design and engineering, structural biology and bioinformatics. The database is accessible at: http://www.bioinsilico.org/CAPSDB. |