| URL: | http://www.bio-bigdata.com/LNCmap |
| Full name: | lncRNA modulator atlas in pan-cancer |
| Description: | LncMAP establishes the correlations among diseases, physiological processes, and the action of small molecule therapeutics by attempting to describe all biological states in terms of lncRNA signatures. It provides a systems-level dissection of lncRNA mediated regulatory perturbations in 20 cancer types, also presented a valuable tool and resource for investigating the function of lncRNAs in cancer. |
| Year founded: | 2017 |
| Last update: | 2017 |
| Version: | v1.0 |
| Accessibility: |
Unaccessible
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| Country/Region: | China |
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| University/Institution: | Harbin Medical University |
| Address: | College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China |
| City: | Harbin |
| Province/State: | Heilongjiang |
| Country/Region: | China |
| Contact name (PI/Team): | Xia Li |
| Contact email (PI/Helpdesk): | lixia@hrbmu.edu.cn |
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The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases. [PMID: 28751672]
Well characterized the connections among diseases, long non-coding RNAs (lncRNAs) and drugs are important for elucidating the key roles of lncRNAs in biological mechanisms in various biological states. In this study, we constructed a database called LNCmap (LncRNA Connectivity Map), available at http://www.bio-bigdata.com/LNCmap/ , to establish the correlations among diseases, physiological processes, and the action of small molecule therapeutics by attempting to describe all biological states in terms of lncRNA signatures. By reannotating the microarray data from the Connectivity Map database, the LNCmap obtained 237 lncRNA signatures of 5916 instances corresponding to 1262 small molecular drugs. We provided a user-friendly interface for the convenient browsing, retrieval and download of the database, including detailed information and the associations of drugs and corresponding affected lncRNAs. Additionally, we developed two enrichment analysis methods for users to identify candidate drugs for a particular disease by inputting the corresponding lncRNA expression profiles or an associated lncRNA list and then comparing them to the lncRNA signatures in our database. Overall, LNCmap could significantly improve our understanding of the biological roles of lncRNAs and provide a unique resource to reveal the connections among drugs, lncRNAs and diseases. |