| URL: | http://crdd.osdd.net/raghava/thpdb |
| Full name: | Therapeutics peptides and proteins |
| Description: | THPdb is a comprehensive database based on approved and approved/investigational therapeutic peptides compiling important information about these peptides, like their description, sequence, indication, mechanism of action, pharmacodynamics, toxicity, metabolism, absorption, half life, volume of distribution, clearance rate, patent information, interaction with other drugs, targets, physicochemical properties, etc. These peptides have been classified into four categories according to their application, making it easy for the user to access them. Therapeutic peptides are modified in different ways so as to alter their properties and then sold under different brand names by various companies. THPdb provides detailed description of such brands in a user-friendly way to enable quick access of relevant information on the peptides. All information compiled in this database has been extracted from research papers, patents, pharmaceutical company websites catering to product details, drugbank, US-FDA and others. |
| Year founded: | 2017 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
|
| Country/Region: | India |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | Institute of Microbial Technology |
| Address: | Sector 39-A, Chandigarh-160036, India |
| City: | Chandigarh |
| Province/State: | |
| Country/Region: | India |
| Contact name (PI/Team): | Gajendra P. S. Raghava |
| Contact email (PI/Helpdesk): | raghava@iiitd.ac.in |
|
THPdb: Database of FDA-approved peptide and protein therapeutics. [PMID: 28759605]
THPdb (http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins. The information in THPdb has been compiled from 985 research publications, 70 patents and other resources like DrugBank. The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance, category or pharmacological class, pharmacodynamics, route of administration, toxicity, target of activity, etc. In addition, we have annotated the structure of most of the protein and peptides. A number of user-friendly tools have been integrated to facilitate easy browsing and data analysis. To assist scientific community, a web interface and mobile App have also been developed. |