| URL: | http://surya.bic.nus.edu.sg/mpid |
| Full name: | MHC-Peptide Interaction Database |
| Description: | To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). |
| Year founded: | 2003 |
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| Accessibility: |
Unaccessible
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| Country/Region: | Singapore |
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| University/Institution: | National University of Singapore |
| Address: | Department of Biochemistry, National University of Singapore, Singapore 119260. |
| City: | Singapore |
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| Country/Region: | Singapore |
| Contact name (PI/Team): | Shoba Ranganathan |
| Contact email (PI/Helpdesk): | shoba@bic.nus.edu.sg |
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MPID: MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules. [PMID: 12538264]
SUMMARY: Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint. |