Database Commons
Database Commons

a catalog of worldwide biological databases

Database Profile

General information

URL: http://aant.icmb.utexas.edu/
Full name: the Amino Acid-Nucleotide Interaction Database
Description: AANT accomplishes this by extracting individual amino acid-nucleotide interactions from structures in the Protein Data Bank, combining and superimposing these interactions into multiple structure files (e.g. 20 amino acids x 5 nucleotides) and grouping structurally similar interactions into more readily identifiable clusters. Using the Chime web browser plug-in, users can view 3D representations of the superimpositions and clusters.
Year founded: 2004
Last update:
Version:
Accessibility:
Manual:
Unaccessible
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Country/Region: United States

Classification and Labelling

Data type:
Data object:
NA
Database category:
Major species:
NA
Keywords:

Contact information

University/Institution: University of Texas at Austin
Address:
City:
Province/State:
Country/Region: United States
Contact name (PI/Team): Andrew D. Ellington
Contact email (PI/Helpdesk): andy.ellington@mail.utexas.edu

Publications

14681388
AANT: the Amino Acid-Nucleotide Interaction Database. [PMID: 14681388]
Hoffman MM, Khrapov MA, Cox JC, Yao J, Tong L, Ellington AD.

We have created an Amino Acid-Nucleotide Interaction Database (AANT; http://aant.icmb.utexas. edu/) that categorizes all amino acid-nucleotide interactions from experimentally determined protein-nucleic acid structures, and provides users with a graphic interface for visualizing these interactions in aggregate. AANT accomplishes this by extracting individual amino acid-nucleotide interactions from structures in the Protein Data Bank, combining and superimposing these interactions into multiple structure files (e.g. 20 amino acids x 5 nucleotides) and grouping structurally similar interactions into more readily identifiable clusters. Using the Chime web browser plug-in, users can view 3D representations of the superimpositions and clusters. The unique collection and representation of data on amino acid-nucleotide interactions facilitates understanding the specificity of protein-nucleic acid interactions at a more fundamental level, and allows comparison of otherwise extremely disparate sets of structures. Moreover, by modularly representing the fundamental interactions that govern binding specificity it may prove possible to better engineer nucleic acid binding proteins.

Nucleic Acids Res. 2004:32(Database issue) | 72 Citations (from Europe PMC, 2022-10-01)

Ranking

All databases:
1867/5380 (65.316%)
Interaction:
329/839 (60.906%)
1867
Total Rank
72
Citations
4
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Record metadata

Created on: 2018-02-09
Curated by:
Lin Liu [2022-09-20]
Hao Zhang [2018-03-15]
Hao Zhang [2018-02-25]
Yang Zhang [2018-02-09]