| URL: | http://sbi.imim.es/cgi-bin/archdb/loops.pl?class=all&set=ArchDB-KI |
| Full name: | ArchDB-KI |
| Description: | ArchDB-KI is a curated classification database of kinase loops EC number 2.7.X.X with functional information of residues. |
| Year founded: | 2004 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | Spain |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: |
NA
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| Keywords: |
| University/Institution: | Universitat Autònoma de Barcelona |
| Address: | |
| City: | |
| Province/State: | |
| Country/Region: | Spain |
| Contact name (PI/Team): | Baldomero Oliva |
| Contact email (PI/Helpdesk): | boliva@imim.es |
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Classification of common functional loops of kinase super-families. [PMID: 15229886]
A structural classification of loops has been obtained from a set of 141 protein structures classified as kinases. A total of 1813 loops was classified into 133 subclasses (9 betabeta(links), 15 betabeta(hairpins), 31 alpha-alpha, 46 alpha-beta and 32 beta-alpha). Functional information and specific features relating subclasses and function were included in the classification. Functional loops such as the P-loop (shared by different folds) or the Gly-rich-loop, among others, were classified into structural motifs. As a result, a common mechanism of catalysis and substrate binding was proved for most kinases. Additionally, the multiple-alignment of loop sequences made within each subclass was shown to be useful for comparative modeling of kinase loops. The classification is summarized in a kinase loop database located at http://sbi.imim.es/archki. |