| URL: | http://www.primate.or.kr/HESAS |
| Full name: | HERVs Expression and Structure Analysis System |
| Description: | The human genome comprises approximately 8% by the HERVs (Human Endogenous RetroViruses) and other long terminal repeat (LTR) like elements. The HESAS (HERVs Expression and Structure Analysis System) database was developed to understand HERVs roles. The database shows expression and structure patterns by HERV elements located in 26,980 genes regions. The HERV expression patterns are indicated as exonization, contain, supply splicing donor, acceptor, TSS (transcriptional start site), and polyA signal. Genomic structure of HERV elements are predicted with retroviral genes (gag, pro, RT, Rnase, Intergrase, and env) by functional domain information and divided into 4 types according to the state of LTR truncation. |
| Year founded: | 2005 |
| Last update: | 2004 |
| Version: | |
| Accessibility: |
Accessible
|
| Country/Region: | Korea, Republic of |
| Data type: | |
| Data object: | |
| Database category: | |
| Major species: | |
| Keywords: |
| University/Institution: | Pusan National University |
| Address: | PBBRC, Interdisciplinary Research Program of Bioinformatics, College of Natural Sciences, Pusan National University, Busan 609-735, Korea. |
| City: | Busan |
| Province/State: | |
| Country/Region: | Korea, Republic of |
| Contact name (PI/Team): | Heui-Soo Kim |
| Contact email (PI/Helpdesk): | khs307@pusan.ac.kr |
|
HESAS: HERVs Expression and Structure Analysis System. [PMID: 15591358]
SUMMARY: HESAS (HERVs Expression and Structure Analysis System) database was developed to understand the human endogenous retroviruses (HERVs) that have an effect on the expression of human functional genes. The database products are generated by the exon-based expressed sequence tag clustering and reconstructing of partial HERV structures that result from various mutations during primate evolution. The expression types were classified according to the existence of splicing, transcriptional start and polyadenylation signal sites. The database currently contains HERV information on 26,981 human genes of exon-intron structure. The HERV elements were inserted into 17,317 of these genes and linked to expression with 898 genes. |