| URL: | http://pubmlst.org/ctropicalis |
| Full name: | Candida tropicalis MLST Databases |
| Description: | This site uses two linked databases powered by the BIGSdb genomics platform. The sequence definition database contains allele sequence and MLST profile definitions whereas the isolate database contains provenance and epidemiological information. |
| Year founded: | 2005 |
| Last update: | 2018-02-14 |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | United Kingdom |
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| University/Institution: | University of Aberdeen |
| Address: | Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom |
| City: | Aberdeen |
| Province/State: | |
| Country/Region: | United Kingdom |
| Contact name (PI/Team): | Frank C. Odds |
| Contact email (PI/Helpdesk): | f.odds@abdn.ac.uk |
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Multilocus sequence typing for differentiation of strains of Candida tropicalis. [PMID: 16272492]
A system is described for typing isolates of the pathogenic fungus Candida tropicalis, based on sequence polymorphisms in fragments of six genes: ICL1, MDR1, SAPT2, SAPT4, XYR1, and ZWF1a. The system differentiated 87 diploid sequence types (DSTs) among a total of 106 isolates tested or 80 DSTs among 88 isolates from unique sources. Replicate isolates from the same source clustered together with high statistical similarity, with the exception of one isolate. However, a clade of very closely related isolates included replicate isolates from three different patients, as well as single isolates from eight other patients. This clade, provisionally designated clade 1, was one of three clusters of isolates with high statistical similarity. Five of six isolates in one cluster that may acquire clade status were resistant to flucytosine. This study adds C. tropicalis to Candida albicans and Candida glabrata as Candida species for which a multilocus sequence typing (MLST) system has been set up. The C. tropicalis MLST database can be accessed at http://pubmlst.org/ctropicalis/. |