| URL: | http://rnact.crg.eu |
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| Description: | a global view of the protein–RNA interactome |
| Year founded: | 2019 |
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| Accessibility: |
Accessible
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| Country/Region: | Spain |
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| University/Institution: | Barcelona Institute of Science and Technology |
| Address: | Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain. |
| City: | Barcelona |
| Province/State: | |
| Country/Region: | Spain |
| Contact name (PI/Team): | Ben Lang |
| Contact email (PI/Helpdesk): | benjamin.lang@crg.eu |
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RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data. [PMID: 30445601]
Protein-RNA interactions are implicated in a number of physiological roles as well as diseases, with molecular mechanisms ranging from defects in RNA splicing, localization and translation to the formation of aggregates. Currently, ?1400 human proteins have experimental evidence of RNA-binding activity. However, only ?250 of these proteins currently have experimental data on their target RNAs from various sequencing-based methods such as eCLIP. To bridge this gap, we used an established, computationally expensive protein-RNA interaction prediction method, catRAPID, to populate a large database, RNAct. RNAct allows easy lookup of known and predicted interactions and enables global views of the human, mouse and yeast protein-RNA interactomes, expanding them in a genome-wide manner far beyond experimental data (http://rnact.crg.eu). |