| URL: | http://www.insect-genome.com/miR-pathway |
| Full name: | integration and visualization of miRNA and KEGG pathways |
| Description: | A pathway database called miR+Pathway is designed by integrating and visualizing the human experimentally validated miRNA-target interactions (MTIs) and KEGG pathways. Researchers can intuitively determine the pathways and the genes in the pathways that are regulated by miRNAs as well as the miRNAs that target the pathways. |
| Year founded: | 2019 |
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| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Zhejiang University |
| Address: | Ministry of Agriculture Key Lab of Agricultural Entomology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China |
| City: | Hangzhou |
| Province/State: | Zhejiang |
| Country/Region: | China |
| Contact name (PI/Team): | Fei Li |
| Contact email (PI/Helpdesk): | lifei18@zju.edu.cn |
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miR+Pathway: the integration and visualization of miRNA and KEGG pathways. [PMID: 30649247]
miRNAs represent a type of noncoding small molecule RNA. Many studies have shown that miRNAs are widely involved in the regulation of various pathways. The key to fully understanding the regulatory function of miRNAs is the determination of the pathways in which the miRNAs participate. However, the major pathway databases such as KEGG only include information regarding protein-coding genes. Here, we redesigned a pathway database (called miR+Pathway) by integrating and visualizing the 8882 human experimentally validated miRNA-target interactions (MTIs) and 150 KEGG pathways. This database is freely accessible at http://www.insect-genome.com/miR-pathway. Researchers can intuitively determine the pathways and the genes in the pathways that are regulated by miRNAs as well as the miRNAs that target the pathways. To determine the pathways in which targets of a certain miRNA or multiple miRNAs are enriched, we performed a KEGG analysis miRNAs by using the hypergeometric test. In addition, miR+Pathway provides information regarding MTIs, PubMed IDs and the experimental verification method. Users can retrieve pathways regulated by an miRNA or a gene by inputting its names. |