| URL: | http://www.gpcrdb.org |
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| Description: | G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. We broadly surveyed the receptor modifications/engineering and methods used to produce all available GPCR crystal and cryo-electron microscopy (cryo-EM) structures, and present an interactive resource integrated in GPCRdb. |
| Year founded: | 2019 |
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| Accessibility: |
Accessible
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| Country/Region: | Denmark |
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| University/Institution: | University of Copenhagen |
| Address: | Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark |
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| Country/Region: | Denmark |
| Contact name (PI/Team): | David E. Gloriam |
| Contact email (PI/Helpdesk): | david.gloriam@sund.ku.dk |
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An online resource for GPCR structure determination and analysis. [PMID: 30664776]
G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed the general bases of receptor activation, signaling, drug action and allosteric modulation, but so far cover only 13% of nonolfactory receptors. We broadly surveyed the receptor modifications/engineering and methods used to produce all available GPCR crystal and cryo-electron microscopy (cryo-EM) structures, and present an interactive resource integrated in GPCRdb ( http://www.gpcrdb.org ) to assist users in designing constructs and browsing appropriate experimental conditions for structure studies. |