| URL: | http://www.isical.ac.in/~bioinfo_miu/miRT/miRT.php |
| Full name: | a database of validated transcription start sites of human microRNAs |
| Description: | MicroRNAs (miRNAs) are small endogeneous non-coding RNAs of about 22nt length. These short RNAs regulate the expression of mRNAs by hybridizing with their 3'-UTRs or by translational repression. They have been shown to take crucial roles in many biological processes. Many of the current studies are focused over how mature miRNAs regulate mRNAs, even though very limited knowledge is there about their transcriptional loci. Primary miRNAs (pri-miRs) are first transcribed from the DNA, followed by the formation of precursor miRNA (pre-miR) by endonucleases activity, which finally produces mature miRNAs. Unfortunately, the identification of the loci of pri-miRs, and the associated information about transcription start sites (TSSs) and promoters is still in progress. There are reported results concerning the TSSs of about 40% of the total mature miRNAs hitherto explored in human. This limited information, presented as the miRT database, is useful for further study on the regulation of miRNAs. |
| Year founded: | 2012 |
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| Accessibility: |
Accessible
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| Country/Region: | India |
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| University/Institution: | Indian Statistical Institute |
| Address: | Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700 108, India |
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| Country/Region: | India |
| Contact name (PI/Team): | Sanghamitra Bandyopadhyay |
| Contact email (PI/Helpdesk): | sanghami@isical.ac.cn |
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miRT: a database of validated transcription start sites of human microRNAs. [PMID: 23200141]
MicroRNAs (miRNAs) are small endogenous non-coding RNAs of about 22 nt in length that take crucial roles in many biological processes. These short RNAs regulate the expression of mRNAs by binding to their 3'-UTRs or by translational repression. Many of the current studies focus on how mature miRNAs regulate mRNAs, however, very limited knowledge is available regarding their transcriptional loci. It is known that primary miRNAs (pri-miRs) are first transcribed from the DNA, followed by the formation of precursor miRNAs (pre-miRs) by endonuclease activity, which finally produces the mature miRNAs. Till date, many of the pre-miRs and mature miRNAs have been experimentally verified. But unfortunately, identification of the loci of pri-miRs, promoters and associated transcription start sites (TSSs) are still in progress. TSSs of only about 40% of the known mature miRNAs in human have been reported. This information, albeit limited, may be useful for further study of the regulation of miRNAs. In this paper, we provide a novel database of validated miRNA TSSs, miRT, by collecting data from several experimental studies that validate miRNA TSSs and are available for full download. We present miRT as a web server and it is also possible to convert the TSS loci between different genome built. miRT might be a valuable resource for advanced research on miRNA regulation, which is freely accessible at: http://www.isical.ac.in/~bioinfo_miu/miRT/miRT.php. |