| URL: | https://cb.imsc.res.in/deduct |
| Full name: | Database of Endocrine Disrupting Chemicals and their toxicity profile |
| Description: | Humans are being exposed to myriad chemicals in their daily environment including those contained in consumer goods, food, pharmaceuticals, and household products. Most of these daily use products were introduced or developed for human benefit, however, exposure to a minority of chemicals in these products can cause deleterious effects through serious damage to several organ systems. One such group of chemicals, namely, Endocrine Disrupting Chemicals (EDCs), have the ability to perturb the normal functioning of the biological system. In order to screen such chemicals in our daily life, we have developed a detailed workflow which was employed to process more than 16000 scientific abstracts to identify EDCs with supporting evidence for endocrine disruption upon exposure based on the observed endocrine-mediated endpoints specific to humans or rodents. Using our workflow, we identified 686 potential EDCs with supporting evidence of systems-level endocrine-mediated endpoints in published literature spanning 1796 research articles specific to humans or rodents |
| Year founded: | 2019 |
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| Accessibility: |
Accessible
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| Country/Region: | India |
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| Major species: |
NA
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| University/Institution: | Institute of Mathematical Sciences |
| Address: | The Institute of Mathematical Sciences (IMSc) 4th Cross Road, CIT Campus, Taramani, Chennai 600113 India |
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| Country/Region: | India |
| Contact name (PI/Team): | Areejit Samal |
| Contact email (PI/Helpdesk): | asamal@imsc.res.in |
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A curated knowledgebase on endocrine disrupting chemicals and their biological systems-level perturbations. [PMID: 31349169]
Human well-being can be affected by exposure to several chemicals in the environment. One such group is endocrine disrupting chemicals (EDCs) that can perturb the hormonal homeostasis leading to adverse health effects. In this work, we have developed a detailed workflow to identify EDCs with supporting evidence of endocrine disruption in published experiments in humans or rodents. Thereafter, this workflow was used to manually evaluate more than 16,000 published research articles and identify 686 potential EDCs with published evidence in humans or rodents. Importantly, we have compiled the observed adverse effects or endocrine-specific perturbations along with the dosage information for the potential EDCs from their supporting published experiments. Subsequently, the potential EDCs were classified based on the type of supporting evidence, their environmental source and their chemical properties. Additional compiled information for potential EDCs include their chemical structure, physicochemical properties, predicted ADMET properties and target genes. In order to enable future research based on this compiled information on potential EDCs, we have built an online knowledgebase, Database of Endocrine Disrupting Chemicals and their Toxicity profiles (DEDuCT), accessible at: https://cb.imsc.res.in/deduct/. After building this comprehensive resource, we have performed a network-centric analysis of the chemical space and the associated biological space of target genes of EDCs. Specifically, we have constructed two networks of EDCs using our resource based on similarity of chemical structures or target genes. Ensuing analysis revealed a lack of correlation between chemical structure and target genes of EDCs. Though our detailed results highlight potential challenges in developing predictive models for EDCs, the compiled information in our resource will undoubtedly enable future research in the field, especially, those focussed towards mechanistic understanding of the systems-level perturbations caused by EDCs. |