| URL: | https://cwtung.kmu.edu.tw/chemdis |
| Full name: | Chemical-Disease Inference System |
| Description: | ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. |
| Year founded: | 2018 |
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| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Kaohsiung Medical University |
| Address: | Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan |
| City: | Kaohsiung |
| Province/State: | Taiwan |
| Country/Region: | China |
| Contact name (PI/Team): | Chun-Wei Tung |
| Contact email (PI/Helpdesk): | cwtung@kmu.edu.tw |
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ChemDIS 2: an update of chemical-disease inference system. [PMID: 30053236]
Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. In this work, we present an update of ChemDIS 2 system featured with more updated datasets and several new functions, including (i) custom enrichment analysis function for single omics data; (ii) multi-omics analysis function for joint analysis of multi-omics data; (iii) mixture analysis function for the identification of interaction and overall effects; (iv) web application programming interface (API) for programmed access to ChemDIS 2. The updated ChemDIS 2 system capable of analyzing more than 430 000 chemicals is expected to be useful for both drug development and risk assessment of environmental chemicals.Database URL: ChemDIS 2 is freely accessible via https://cwtung.kmu.edu.tw/chemdis. |