| URL: | http://www.exoRBase.org |
| Full name: | mRNA, lncRNA and circRNA in extracellular vesicles |
| Description: | exoRBase is a repository of extracellular vesicles (EVs) long RNAs (exLRs) derived from RNA-seq data analyses in different human body fluids. exoRBase 2.0 houses 19,643 mRNAs, 15,645 lncRNAs and 79,084 circRNAs obtained from ∼1000 human blood, urine, cerebrospinal fluid (CSF) and bile samples. |
| Year founded: | 2018 |
| Last update: | 2021-11 |
| Version: | v2.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Fudan University |
| Address: | Shanghai Medical College, Fudan University, Shanghai 200032, China |
| City: | Shanghai |
| Province/State: | Shanghai |
| Country/Region: | China |
| Contact name (PI/Team): | Shenglin Huang |
| Contact email (PI/Helpdesk): | slhuang@fudan.edu.cn |
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exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids. [PMID: 34918744]
Extracellular vesicles (EVs) are small membranous vesicles that contain an abundant cargo of different RNA species with specialized functions and clinical implications. Here, we introduce an updated online database (http://www.exoRBase.org), exoRBase 2.0, which is a repository of EV long RNAs (termed exLRs) derived from RNA-seq data analyses of diverse human body fluids. In exoRBase 2.0, the number of exLRs has increased to 19 643 messenger RNAs (mRNAs), 15 645 long non-coding RNAs (lncRNAs) and 79 084 circular RNAs (circRNAs) obtained from ∼1000 human blood, urine, cerebrospinal fluid (CSF) and bile samples. Importantly, exoRBase 2.0 not only integrates and compares exLR expression profiles but also visualizes the pathway-level functional changes and the heterogeneity of origins of circulating EVs in the context of different physiological and pathological conditions. Our database provides an attractive platform for the identification of novel exLR signatures from human biofluids that will aid in the discovery of new circulating biomarkers to improve disease diagnosis and therapy. |
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exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. [PMID: 30053265]
Exosomes, which are nanosized endocytic vesicles that are secreted by most cells, contain an abundant cargo of different RNA species that can modulate the behavior of recipient cells and may be used as circulating biomarkers for diseases. Here, we develop a web-accessible database (http://www.exoRBase.org), exoRBase, which is a repository of circular RNA (circRNA), long non-coding RNA (lncRNA) and messenger RNA (mRNA) derived from RNA-seq data analyses of human blood exosomes. Experimental validations from the published literature are also included. exoRBase features the integration and visualization of RNA expression profiles based on normalized RNA-seq data spanning both normal individuals and patients with different diseases. exoRBase aims to collect and characterize all long RNA species in human blood exosomes. The first release of exoRBase contains 58 330 circRNAs, 15 501 lncRNAs and 18 333 mRNAs. The annotation, expression level and possible original tissues are provided. exoRBase will aid researchers in identifying molecular signatures in blood exosomes and will trigger new exosomal biomarker discovery and functional implication for human diseases. |