| URL: | http://bioinfo.icb.ufmg.br/yvis |
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| Description: | Y-Vis is a web-based platform that allows the analysis of antibody sequences through a new visualization called Collier des Diamants. This new visualization is based on the IMGT/Collier de Perles representation, and provides information on the amino acids present in the variable domain of an antibody chain together with their position in the conserved beta-strands and loops that define the antibody structure. |
| Year founded: | 2019 |
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Accessible
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| Country/Region: | Brazil |
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| University/Institution: | Federal University of Minas Gerais |
| Address: | Laboratory of Synthetic Biology and Biomimetics, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil |
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| Country/Region: | Brazil |
| Contact name (PI/Team): | Milene B Carvalho |
| Contact email (PI/Helpdesk): | milenebc@ufsj.edu.br |
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Yvis: antibody high-density alignment visualization and analysis platform with an integrated database. [PMID: 31106372]
As antibodies are a very important tool for diagnosis, therapy, and experimental biology, a large number of antibody structures and sequences have become available in recent years. Therefore, tools that allow the analysis, comparison, and visualization of this large amount of antibody data are crucially needed. We developed the antibody high-density alignment visualization and analysis (Yvis) platform to provide an innovative, robust and high-density data visualization of antibody sequence alignments, called Collier de Diamants. The Yvis platform also provides an integrated structural database, which is updated weekly, and many different search and filter options. This platform can help to formulate hypotheses concerning the key residues in antibody structures or interactions to improve the understanding of antibody properties. The Yvis platform is available at http://bioinfo.icb.ufmg.br/yvis/. |