| URL: | https://endometdb.utu.fi |
| Full name: | Turku Endometriosis database |
| Description: | This database is an interactive web-based user interface for browsing the gene expression database of collected samples without the need for computational skills. The EndometDB incorporates the expression data from 115 patients and 53 controls, with over 24000 genes and clinical features, such as their age, disease stages, hormonal medication, menstrual cycle phase, and the different endometriosis lesion types. Using the web-tool, the end-user can easily generate various plot outputs and projections, including boxplots, and heatmaps and the generated outputs can be downloaded in pdf-format. |
| Year founded: | 2020 |
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| Accessibility: |
Accessible
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| Country/Region: | Finland |
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| University/Institution: | University of Turku |
| Address: | Institute of Biomedicine, Research Center for Integrative Physiology and Pharmacology, University of Turku Institute of Medicine, Sahlgrenska Academy, 405 30 Gothenburg University, Gothenburg, Sweden Tero Aittokallio Department of Mathematics and Statistics, University of Turku Institute for Molecular Medicine Finland (FIMM), University of Helsinki Department of Obstetrics and Gynecology, University of Turku, and Turku University Hospital |
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| Province/State: | Turku |
| Country/Region: | Finland |
| Contact name (PI/Team): | Tero Aittokallio |
| Contact email (PI/Helpdesk): | matti.poutanen@utu.fi |
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A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions. [PMID: 32859947]
Endometriosis is a common inflammatory estrogen-dependent gynecological disorder, associated with pelvic pain and reduced fertility in women. Several aspects of this disorder and its cellular and molecular etiology remain unresolved. We have analyzed the global gene expression patterns in the endometrium, peritoneum and in endometriosis lesions of endometriosis patients and in the endometrium and peritoneum of healthy women. In this report, we present the EndometDB, an interactive web-based user interface for browsing the gene expression database of collected samples without the need for computational skills. The EndometDB incorporates the expression data from 115 patients and 53 controls, with over 24000 genes and clinical features, such as their age, disease stages, hormonal medication, menstrual cycle phase, and the different endometriosis lesion types. Using the web-tool, the end-user can easily generate various plot outputs and projections, including boxplots, and heatmaps and the generated outputs can be downloaded in pdf-format.Availability and implementationThe web-based user interface is implemented using HTML5, JavaScript, CSS, Plotly and R. It is freely available from https://endometdb.utu.fi/ . |