| URL: | http://bioinfo.life.hust.edu.cn/FFLtool |
| Full name: | a web server for detecting potential feed forward loop |
| Description: | FFLtool is a webserver for analyzing Feed Forward Loop (FFL) regulatory motifs among transcription factors (TFs), microRNAs (miRNAs) and genes. FFLs potentially regulate thousands of target genes in facilitating spatiotemporal avoidance or noise buffering and play important roles in biological processes and diseases (see Refs. PMIDs: 20157565 and 24307685). It integrated TF-target data from hTFtarget and miR-target data from several predicted and validated databases. Except for identifying FFLs, FFLtools can also be used to search miR-target and TF-target information. |
| Year founded: | 2020 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Huazhong University of Science and Technology |
| Address: | Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China. |
| City: | Wuhan |
| Province/State: | Hubei |
| Country/Region: | China |
| Contact name (PI/Team): | An-Yuan Guo |
| Contact email (PI/Helpdesk): | guoay@hust.edu.cn |
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FFLtool: a web server for transcription factor and miRNA feed forward loop analysis in human. [PMID: 31830251]
SUMMARY: Transcription factors (TFs) and microRNAs (miRNAs) are two kinds of important regulators for transcriptional and post-transcriptional regulations. Understanding cross-talks between the two regulators and their targets is critical to reveal complex molecular regulatory mechanisms. Here, we developed FFLtool, a web server for detecting potential feed forward loop (FFL) of TF-miRNA-target regulation in human. In FFLtool, we integrated comprehensive regulations of TF-target and miRNA-target, and developed two functional modules: (i) The 'FFL Analysis' module can detect potential FFLs and internal regulatory networks in a user-defined gene set. FFLtool also provides three levels of evidence to illustrate the reliability for each FFL and enrichment functions for co-target genes of the same TF and miRNA; (ii) The 'Browse FFLs' module displays FFLs comprised of differentially or specifically expressed TFs and miRNAs and their target genes in cancers. FFLtool is a valuable resource for investigating gene expression regulation and mechanism study in biological processes and diseases. |