| URL: | http://www.bio-bigdata.net/LnCeVar |
| Full name: | a comprehensive database of genomic variations that disturb ceRNA network regulation |
| Description: | LnCeVar is a comprehensive database that aims to provide genomic variations that disturb lncRNA-associated ceRNA network regulation for six species curated from the published literature and high-throughput data sets. LnCeVar curated 119,501 variation–ceRNA events from thousands of samples and cell lines, including: (i) more than 2,000 experimentally supported circulating, drug-resistant and prognosis-related lncRNA biomarkers; (ii) 11,418 somatic mutation–ceRNA events from TCGA and COSMIC; (iii) 112,674 CNV–ceRNA events from TCGA; (iv) 67,066 SNP–ceRNA events from the 1000 Genomes Project. |
| Year founded: | 2020 |
| Last update: | |
| Version: | v1.0 |
| Accessibility: |
Unaccessible
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| Country/Region: | China |
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| University/Institution: | Harbin Medical University |
| Address: | College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China |
| City: | Harbin |
| Province/State: | Heilongjiang |
| Country/Region: | China |
| Contact name (PI/Team): | Xia Li |
| Contact email (PI/Helpdesk): | lixia@hrbmu.edu.cn |
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LnCeVar: a comprehensive database of genomic variations that disturb ceRNA network regulation. [PMID: 31617563]
LnCeVar (http://www.bio-bigdata.net/LnCeVar/) is a comprehensive database that aims to provide genomic variations that disturb lncRNA-associated competing endogenous RNA (ceRNA) network regulation curated from the published literature and high-throughput data sets. LnCeVar curated 119 501 variation-ceRNA events from thousands of samples and cell lines, including: (i) more than 2000 experimentally supported circulating, drug-resistant and prognosis-related lncRNA biomarkers; (ii) 11 418 somatic mutation-ceRNA events from TCGA and COSMIC; (iii) 112 674 CNV-ceRNA events from TCGA; (iv) 67 066 SNP-ceRNA events from the 1000 Genomes Project. LnCeVar provides a user-friendly searching and browsing interface. In addition, as an important supplement of the database, several flexible tools have been developed to aid retrieval and analysis of the data. The LnCeVar-BLAST interface is a convenient way for users to search ceRNAs by interesting sequences. LnCeVar-Function is a tool for performing functional enrichment analysis. LnCeVar-Hallmark identifies dysregulated cancer hallmarks of variation-ceRNA events. LnCeVar-Survival performs COX regression analyses and produces survival curves for variation-ceRNA events. LnCeVar-Network identifies and creates a visualization of dysregulated variation-ceRNA networks. Collectively, LnCeVar will serve as an important resource for investigating the functions and mechanisms of personalized genomic variations that disturb ceRNA network regulation in human diseases. |